噬菌体治疗细菌性感染的进展

Research Progress in Phage Therapy of Bacterial Infections

噬菌体是自然界中广泛存在的细菌病毒,作为细菌的天然杀手,在细菌性感染尤其是多重耐药菌感染的治疗方面具有抗生素无法比拟的优势。综述了利用活噬菌体治疗细菌性感染的早期研究及近几年的初步临床试验结果、利用噬菌体裂解酶治疗细菌性感染的最新进展,指出了噬菌体治疗真正得以应用所面临的主要障碍并综述分析了一些具有一定可行性的解决方案,以期为噬菌体治疗的研究和应用提供参考,并推动噬菌体治疗研究的进一步发展。

Bacteriophage is the most abundant bacterial virus in nature.As the natural bacterium killer,it displays exceptionally more advantages than antibiotics to the treatment of bacterial infections especially multi-drug resistant bacterium.The historical and updated research progress in the treatment of bacterial infections employing live bacteriophage and bacteriophage-derived lysin was summarized.The major obstacles in phage therapy and some feasible resolutions were discussed.It is expected that phage therapy will attract renewed interest increasingly and will play more important role in the coming post-antibiotic era.