6种氟喹诺酮类药物对粪肠球菌的体外抑菌活性

Activity of 6 fluoroquinolones against Enterococcus faecalis in vitro

目的检测粪肠球菌对氟喹诺酮类药物的敏感性,指导临床合理用药。方法用二倍琼脂稀释法检测6种氟喹诺酮类药物对178株粪肠球菌临床分离株的体外抑菌活性。结果在6种氟喹诺酮类药物中,妥舒沙星抑菌活性最强,其次是加替沙星和司帕沙星,氧氟沙星和环丙沙星的抑菌活性最差。结论氟喹诺酮类抗菌药新品种妥舒沙星、加替沙星和司帕沙星对粪肠球菌的抑菌活性较老一代药物更强。

Objective To determine the susceptibility of fluoroquinolones against Enterococcus faecalis for the guidance of rational use of antibiotics. Methods The activity of 6 fluoroquinolones in vitro against 178 clinical isolates of Enterococcus faecalis was compared by agar dilution method. Results Among 6 fluoroquinolones,tosufloxacin was the most active drug,while the activi- ty of ofloxacin and ciprofloxacin was the worst. In decreasing order, the relative activity （MIC50s 、 MIC90s） of 6 fluoroquinolones against Enterococcus faecalis was as follows： tosufloxacin（MIC50,0.50 mg/L ; MIC90,2.00 mg/L） 〉 gatifloxacin（MIC50,1.00 mg/ L;MIC90,4.00 mg/L） ,sparfloxacin（MICS0,1.00 mg/L; MIC90,4.00 rag/L） 〉 levofloxacin（MIC50,2. 00 mg/L; MIC90,16.00 mg/L） 〉ofloxacin （MICS0,4.00 rag/L; MIC90,64.00 mg/L）, cipfloxacin（MICS0,4.00 mg/L; MIC90,64.00 mg/L）. Conclusion New fluoroquinolones such as tosufloxacin, gatifloxacin and sparfloxacin were more active against Enterococcus faecalis than the previous fluoroquinolones.