艾滋病暴露前预防的研究进展

Research progress in pre-exposure prophylaxis of HIV transmission

全球艾滋病新发感染依然严峻,干预策略仍然不能普遍有效,亟需新的高效的干预措施整合到生物医学预防-行为预防-社会结构预防的综合模式当中,如暴露前预防。猕猴和小鼠模型证明了它的有效性和安全性,但结果仅限于指导临床试验的设计,因为只有临床试验才能真正说明暴露前预防能否有效阻断艾滋病传播。该策略成功的关键因素有两点:一是个人风险决策;二是社会环境易感性。暴露前预防在艾滋病领域拥有巨大潜能,需要及早纳入计划并拟定相关的应急方案。

In the context of worldwide increasing new cases of HIV infection and less optimistic intervention strategies,it will be essential to develop new,highly effective integrated interventions to combine with biomedical,behavioral and social prevention.Preclinical researches in animal models of macaques and mice have proved the efficacy and safety of pre-exposure prophylaxis（PrEP）,however they remain at a stage of guiding the design of clinical trails and only the result of clinical trails may ultimately determine if PrEP can truly interrupt HIV transmission.Not only personal risk strategy for HIV infection,but also social and environmental vulnerability will be key to successful PrEP programs.PrEP has great potential in the area of HIV prevention and requires early planning and comprehensive implementation.