110例药品不良反应报告分析

Adverse Drug Reactions: Analysis of 110 Cases

目的:分析濮阳市人民医院药品不良反应(ADR)发生的特点和规律,为临床合理、安全用药提供参考。方法:采用回顾性分析方法,对我院2007年1月—2010年6月收集的110例药品不良反应报告进行分类统计分析。结果:110例药品不良反应中,60岁以上患者较多,共64例,占58.18%;静脉给药引起的药品不良反应为79例,占71.82%;由抗菌药物引起的药品不良反应最多,共37例,占33.64%,其次为中药制剂,共19例,占17.27%;临床表现以皮肤及其附件损害最为多见,有39例占35.45%。结论:应以抗菌药物和中药制剂为重点,加强医院药品不良反应的监测工作,减少或避免药品不良反应的发生,保障患者用药安全。

OBJECTIVE：To analyze the characteristics and regularities of the adverse drug reactions（ADRs） occurred in Puyang People＇s Hospital for references of clinical rational drug use.METHODS： By a retrospective study,a total of 110 ADR cases collected in our hospital from Jan.2007 to Jun.2010 were analyzed statistically.RESULTS： Of the 110 ADR cases,64（58.18%） aged above 60 years;79（71.82%） were induced by intravenous administration;antibiotics were the major drugs which induced ADR in 37 cases（33.64%）,followed by Chinese medicine in 19 cases（17.27%）.Lesions of skin and its appendants were the most common clinical manifestations of ADRs with 39 cases（35.45%）.CONCLUSION： The ADR monitoring should be intensified with an emphasis laid to antimicrobial drugs and traditional Chinese medicine so as to lessen or avoid the occurrence of ADRs and ensure patients＇ medication safety.