复骨丸防治激素性早期股骨头缺血性坏死的血液流变学及脂代谢的实验研究

Study of Experiment on hemorheology and Lipid Metabolism About Zhushifuguwan Prevention and Cure Early Stage of Steroid-Induced Avascular Necrosis of Femoral Head

目的：探讨复骨丸防治激素性早期股骨头缺血性坏死对血液流变学及脂质代谢的作用。方法：采用贺氏造模法制成大白兔激素性早期股骨头缺血性坏死模型，分成正常、造模、预防、治疗、阳性对照共５ 组。分别进行血液流变学及脂质代谢中相关数据变化的观察和比较。结果：预防组和治疗组动物血浆和全血粘度、胆固醇、甘油三酯、高密度和低密度脂蛋白、载脂蛋白Ａ 和Ｂ、血碱性磷酸酶及尿脂均明显低于单纯造模组（Ｐ＜ ０．０５），其中，预防组的效果最优。结论：复骨丸可能具有保护肝脏，减少其受损程度，调节激素后脂肪在体内的转移过程，减轻血管壁的受损和减少动脉硬化，抗血栓等综合作用有关。

Objective:To investigate the protective and cure effects of zhushifuguwan on the steroid induced avascular necrosis of femoral head.Methods:We built He's model to observe the changes on hemorheology and fatty metabolism.Resultes:By comparison with the simple module group,the data of the plasma,blood viscosity,Cholesterol,triglycenide,high (low) lipoprtein,Apolipoprotein A(B),Alkaline phosphatase and uriue fat in the defended groups and the treated groups obviously lower than of those in it.The defended group's results is the best.Conclusion:zhushifuguwan can prtect the liver,regulate the fat transfer in the body,resist thrombus,reduce the damage of vascular wall and arteriosclerosis.