抑郁症脑脊液生长抑素的测定

Cerebrospinal fluid level of somatostatin in depressed patients

目的： 进一步探讨抑郁症可能的生化病理机制。 方法： 采用非平衡放射免疫测定法（ＲＩＡ） 对符合入组标准的２６ 例抑郁症患者和２０例对照者脑脊液（ＣＳＦ） 中生长抑素（ＳＳ） 含量进行检测。 结果： 抑郁症患者ＣＳＦ中ＳＳ水平（１９．５３±９．４３） ｎｇ／Ｌ明显低于对照组（２８．５７±１６．０３） ｎｇ／Ｌ；抑郁症患者ＣＳＦ中ＳＳ水平与汉密顿抑郁量表（ＨＡＭＤ） 总分呈显著负相关（ｒ＝ － ０．４７９）。 结论： 抑郁症发病与脑ＳＳ水平低下有关。

Objective:To study the relationship between cerebrospinal fluid(CSF) level of somatostatin and depression. Method:CSF level of somatostatin (SS) level was determined in 26 patients with diagnosis of endogenous depression and 20 normal matched controls. Results:CSF SS level was significantly lower in the depressed (19 53±9 43)ng/L than control group (28 57±16 03)ng/L.There was significant negative correlation between the HAMD total score and CSF SS level ( r =-0 479 in depressed subjects. Conclusion:Lowered cerebral somatostatin level might play an important role in the patholphysiology of depression.