精神分裂症与一氧化氮关系初探

Preliminary investigation of the relationship between nitric oxide and schizophrenia

目的： 确定精神分裂症与一氧化氮的关系。 方法： 使用李恩明改良的Ｇｒｉｅｓｓ法测定９例阴性症状精神分裂症， １０ 例阳性症状精神分裂症和１０例正常人血清中一氧化氮含量。 结果： 阳性症状精神分裂症患者血清一氧化氮明显高于正常组 （Ｐ＜ ０．０１）， 阴性症状精神分裂症患者血清一氧化氮含量明显低于正常组（Ｐ＜ ０．０１）。 结论： 一氧化氮作为中枢神经系统的信使分子， 很可能在精神分裂症发病机制中起到一定作用。

Objective:To study the relationship between schizophrenia and nitric oxide. Method:The serum nitric oxide level of nine schizophrenic patients with negative symptoms (type Ⅱ),ten with positive symptoms (type Ⅰ)and ten normal controls were determined using Griesss technique. Results:The serum nitric oxide level of type Ⅰ schizophrenia was significantly higher,while type Ⅱ lower than normal controls (both P<0 01 ). Conclusion:Nitric oxide,as a new neurotransmitter,might be involved in the pathogenesis of schizophrenia.