益欣康泰胶囊对高原红细胞增多症患者体内氧自由基代谢的影响

EFFECT OF YIXINKANGTAI ON METABOLISM OF FREE RADICALS IN PATIENTS WITH HIGH ALTITUDE POLYCYTHEMIA

目的：观察益欣康泰胶囊对高原红细胞增多症（ＨＡＰＣ）患者体内氧自由基代谢指标超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ—Ｐｘ）活力和丙二醛（ＭＤＡ）含量的影响。方法：在海拔３ ３００ｍ 地区选择１０２ 例ＨＡＰＣ患者进行了服用益欣康泰前后体内ＳＯＤ、ＧＳＨ—Ｐｘ 活性和血清中ＭＤＡ含量的测定。结果：表明该药能明显升高ＨＡＰＣ患者体内的ＳＯＤ与ＧＳＨ—Ｐｘ 活性（Ｐ＜ ００１），同时还有降低血中ＭＤＡ 含量的作用（Ｐ＜ ００１）。结论：说明益欣康泰对ＨＡＰＣ患者体内的氧自由基代谢失衡具有良好的调节和改善作用。

To observe the effect of Yixinkangtai on the marks of metabolism of free radicals in high altitude polycythemia(HAPC),including superoxide dismutase(SOD),glutathion peroxide(GSH-Px) and malondialdehyde(MDA).Methods:102 patients with HAPC were selected at high altitude(3 300m)and SOD,GSH-Px and MDA were measured before and after taking Yixinkangtai.Results:The drug dould significantly increase the activities of SOD and GSH-Px( P <0 01)and decrease the level of MDA( P <0 01)in HAPC.Conclusions:The drug can improve and modulate the metabolism of free radicals in HAPC and may be valuable to prevent and treat for HAPC.$$$$