血清S-CD105监测乳腺癌术后复发转移的意义

Clinical Significance of Serum S-CD105 Level of Patients with Postoperative Recurrent and Metastatic Breast Cancer

探讨复发转移性乳腺癌患者血清S-CD105表达情况及其临床意义。用酶联免疫吸附实验(ELISA)检测50例复发转移性乳腺癌,20例乳腺良性疾病及15例健康女性血清S-CD105的浓度;用微粒子化学发光法检测复发转移患者同期血清CEA、CA15-3的浓度。复发转移性乳腺癌患者血清S-CD105表达明显升高。单项检测S-CD105优于CEA、CA15-3,与CEA和CA15-3联合检测表达相似。血清S-CD105可能对监测乳腺癌患者术后复发转移有重要临床价值。

To explore the levels and clinical significance of serum S--CD105 of patients with postoperative recurrent and me tastatic breast cancer. Serum S--CD105 of 50 postoperative patients with recurrent and metastatic breast cancer, 20 patients with breast benign disease, and 15 healthy controls was detected by ELISA. CEA, CA15--3 of the same patients were measured by micropartiele chemilumin--escence immunoassay in corresponding period. The serum S--CD105 levels of the patients with postoperative recurrent and metastatic breast cancer rise up obviously. The positive rate of serum S-CD105 is higher than CEA, CA15-3 as a signal marker, but has no difference with combining test of CEA and CA15-3. It is expected to he a marker for the diagnosis of recurrence and metastasis of breast cancer.