儿童孤独症相关因素的病例对照研究

Case-control Study on Correlation Factors of Childhood Autism

目的:探讨孤独症发病的相关危险因素。方法:对符合DSM-IV孤独症诊断标准的孤独症儿童40名与年龄、性别均衡的正常儿童40名进行病例对照研究。结果:孤独症相关因素调查表中的8个相关因素,经过卡方检验有统计学意义,即父亲大专及以上学历(P<0.01),母亲大专及以上学历(P<0.01),先兆流产(P<0.05),母亲孕早期感冒(P=0.01),孕周异常(P<0.01),缺氧窒息(P<0.01),高热惊厥(P<0.01),父亲性格内向(P<0.01)与孤独症相关。结论:相关因素父亲大专及以上学历,母亲大专及以上学历,先兆流产,孕早期感冒,孕周异常,缺氧窒息,高热惊厥,父亲性格内向与孤独症相关。

Objective：To identify potential correlation factors of autism.Methods：40 children with autism（The Diagnostic and Statistical Manual of Mental Disorders,fourth edition,DSM-IV）and 40 normal children matched by sex and age were investigated respectively.Results：There was association between eight risk factors in related factors questionnaire and childhood autism,after Chi-square test,that was,higher father＇s education level（P0.01）,higher mother＇s education level（P0.01）,threatened abortion（P 0.05）,early pregnancy colds（P = 0.01）,abnormal gestational age（P0.01）,hypoxia-asphyxia（P0.01）,febrile seizures（P0.01）,father introversion（P0.01）.Conclusion：There was association between eight correlation factors in related factors questionnaire and childhood autism,that was,father＇s cultural level above university,mother＇s cultural level above university,threatened abortion,early pregnancy colds,abnormal gestational age,hypoxia-asphyxia,febrile seizures,father introversion.