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肿瘤坏死因子-α与幽门螺杆菌相关性胃炎的关系研究

The Relationship between antral mucosal tumor necrosis factor- concentration and Helicobacter Pylori-associated gastritis
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摘要 目的探讨胃窦粘膜肿瘤坏死因子-α与幽门螺杆菌相关性胃炎之间的关系。方法应用放射免疫法(RIA)检测90例接受胃镜检查患者的胃窦粘膜肿瘤坏死因子-α的含量,比较HP感染与非感染胃炎患者之间的差异。其中,胃粘膜正常者5例,单纯性慢性胃炎(CG)30例,十二指肠球部溃疡(Du)35例,胃溃疡(GU)20例。结果90例受检者中,HP感染57例(63.33%)的胃粘膜TNF-α含量明显高于33例非HP感染者(P<0.01)。中度胃炎TNF-α含量明显高于轻度胃炎,活动性胃炎又明显高于非活动性胃炎(P均<0.05)。结论HP感染可诱导胃粘膜炎症细胞合成或释放TNF-α。 Objective To investigate the relationship between antral mucosal tumor necrosis factor- concentration and Helicobacter Pylori associated gastritis Method The gastric mucosal biopsies were obtained from 90 patients whose endoscopic and pathologic diagnosis were normal(n=5), Chronic gastritis(n=30), duodenal bulbar ulcer(n=35), gastric ulcer(n=20), level of TNF- in gastric biogsy homogenate supernatant fluid were measured by radioimmunoassay Results 57 of 90 patients were infected by Helicobacter Pylori(6333%) The mucosal level of TNF- were significantly higer in H Pylori-positive patients than in those negative patients (P<001) TNF- level were significantly high in modrate gastritis than in those with mild gastritis and were signicantly higher in active gastritis than in those with inactive gastritis both(P<001) Conclusion This study indicates that a strong correlation exits between mucosal TNF- level and histologicol severity in H Pylori-associated gastritis TNF- may play a part in the pathogenesis of gastric mucosal damage in response to HP
出处 《医学文选》 1999年第1期2-4,共3页 Anthology of Medicine
关键词 幽门螺杆菌 肿瘤坏死因子 胃粘膜 慢性 胃炎 Tumor necrosis factor-\ Helicobacter PyloriGastric mucosa\ Chronic gastrtis
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