糖耐量正常人群中胰岛素抵抗相关因素的调查与分析

An Analysis and Survey of Related Factors of Insulin Resistance in People with Normal Tolerance

目的：了解糖耐量正常人群中胰岛素抵抗的相关因素。方法：对口服７５ 克葡萄糖耐量（ＯＧＴＴ）试验正常的９５２ 人同时进行空腹及服糖后２小时的血浆胰岛素、空腹血浆总胆固醇和甘油三酯水平的测定。结果：胰岛素敏感性指数在超重组（－ ６．８２±０．５５）、高血压组（－ ６．７９±０．４３）、高甘油三酯组（－ ６．６８±０．４９）显著低于正常对照组（－ ６．５４±０．３６），Ｐ＜ ０．０１，高胆固醇组无显著性差异。假定正常对照组的胰岛素敏感性为１．０，超重组、高血压组、高甘油三酯组的胰岛素敏感性分别为０．７６、０．７８、０．８７。胰岛素抵抗的发生率经常吸烟组（６７．３％ ）高于不吸烟组（４８．９％ ）和偶然吸烟组（５５．１％ ），轻体力劳动组（５６．９％ ）高于中、重体力劳动组（４６．７％ ），Ｐ＜ ０．０５。结论：正常糖耐量人群中存在胰岛素抵抗，常与超重、高血压和高甘油三酯伴行，经常吸烟可能是胰岛素抵抗的原因之一，胆固醇似乎与胰岛素抵抗关系不大。

Objective:To explore the related factors of insulin resistance in people with normal glucose tolerance.Methods:We measured the levels of plasma glucose,insulin of fast and 2 hours after 75 g OGTT,fasting total plasma cholesterol and triglyceride in 952 persons with normal glucose tolerance.Results:Insulin susceptibility index(ISI) was significantly lower in the overweight,hypertension and abnormal triglyceride groups( P <0 01) when compared with the control group.Insulin resistance in people with light physical activities was obviously higher than that in people with middle and heavy physical activities,and insulin resistance in smokers was much higher than that in non smoking people.Conclusion:Insulin resistance can be observed in people with normal glucose tolerance,accompanied by over weight,hypertension and hyper triglyceride.Smoking may increase insulin resistance,while sports might decrease it.