盐酸特拉唑嗪对细菌性前列腺炎模型大鼠血浆中左氧氟沙星浓度的影响

Influence of Terazosin on Plasma Concentration of Levofloxacin in Rats with Bacterial Prostatitis

目的:研究盐酸特拉唑嗪对细菌性前列腺炎模型大鼠血浆中左氧氟沙星浓度的影响,并探讨二者协同作用机制。方法:取大鼠建立细菌性前列腺炎模型,随机分为实验组与对照组,每组60只,实验组大鼠灌服盐酸特拉唑嗪溶液(0.44mg·kg-1),对照组同时灌服溶媒,12h后重复1次并立即给2组大鼠静脉注射左氧氟沙星溶液(44mg·kg-1),分别于注射给药后1、3、7.5、15、30、60、120、240、480、720min断头取血,采用高效液相色谱法测定其中左氧氟沙星血药浓度。结果:与对照组比较,实验组大鼠血浆中左氧氟沙星浓度无显著性差异(P>0.05)。结论:盐酸特拉唑嗪对细菌性前列腺炎模型大鼠血浆中左氧氟沙星的浓度无明显影响,前者不是通过增加后者的血药浓度,而可能是通过增加后者在组织中的浓度来提高治疗前列腺炎的效果。

OBJECTIVE： To study the influence of terazosin on plasma concentration of levofloxacin in rats with bacterial prostatitis, and to discuss the corporation mechanism of terazosin and levofloxacin. METHODS： Bacterial prostatitis model had been established and randomly divided rats into experimental group and control group （n=60）. Experimental group was given terazosin 0.44 mg·kg-1 for oral administration and control group was given solvent. Both groups were given drugs once more after 12 h and injected with levofloxacin 44 mg·kg-1 immediately. Plasma sample was collected 1, 3, 7.5, 15, 30, 60, 120, 240, 480 and 720 min after administration. The plasma concentration of levofloxacin was detected by HPLC. RESULTS： There was no significant difference in plasma concentration of levofloxacin between two groups （P0.05）. CONCLUSION： Terazosin has no significant influence on plasma concentration of levofloxacin in rats with bacterial prostatitis, and terazosin improves the effect of levofloxacin on prostatitis by increasing the concentration of levofloxacin in tissue not in plasma.