期刊文献+

维生素D3与支气管哮喘 被引量:7

Vitamin D3 and bronchial asthma
原文传递
导出
摘要 支气管哮喘在世界各国都有逐年上升的趋势,大量研究显示其发生与免疫调节有密切关系,而维生素D3在支气管哮喘有其特定免疫调节机制,可通过调节细胞因子、调节性T细胞、基质金属蛋白酶-9等对支气管哮喘起到一定作用.维生素D3对支气管哮喘免疫调节可为临床有效治疗哮喘提供一定的理论依据,并最终为支气管哮喘患儿提供新的免疫治疗方法. The morbility of bronchial asthma is gradually increasing year by year all over the world. Numerous studies have demonstrated that bronchial asthma is close related with immunoregulation. Vitamin D3 is involved to immune regulatory mechanisms in bronchial asthma, including regulating cytokine, Treg, matrix metalloproteinases-9. Considering the influence of vitamin D3 on the immune regulatory of bronchial asthma, it is provided a theory evidence that vitamin D can be used in the treatment of bronchial asthma effectivly and a novel method of immune treatment for children with bronchial asthma eventually.
出处 《国际儿科学杂志》 2011年第1期15-17,共3页 International Journal of Pediatrics
关键词 维生素D3 维生素D受体 支气管哮喘 免疫 Vitamin D3 Vitamin D receptor Bronchial asthma Immune
  • 相关文献

参考文献18

  • 1Litonjua AA,Weiss ST.Is Vitamin D deficiency to blame for the asthma epidemic.J Allergy Clin Immunol,2007,120(5):1031-1035.
  • 2Kuro-o M.Klotho in chronic kidney discase-what's new.Nephrol Dial Transplant,2009,24(6):1705-1708.
  • 3Chun RF,Adams JS,Hewison M,et al.Back to the futura:a new look at old vitamin D.J Endocrino1,2008,198(2):261-269.
  • 4Raby BA,Silverman EK,Lasams R,et al.Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes.Hum mol Genet,2003,12(16):1973-1979.
  • 5Bluestone JA,Abbas AK.Natural versus adaptive regulatory T cells.Nat Rev Immunol,2003,3(3):253-257.
  • 6Shi HZ,Li S,Xie ZF,et al.Regulatory CD4 + CD25 +T lymphocytes in peripheral blood from patients with atopic asthma.Clin Immunol,2004,113(2):172-178.
  • 7罗征秀,刘恩梅,邓兵,李欣,陈坤华,王莉佳,黄英,符州.Foxp3表达与CD_4^+CD_(25)^+调节性T细胞在儿童哮喘发病中的作用[J].中华儿科杂志,2006,44(4):267-271. 被引量:41
  • 8Gombart AF,Borregaard N,Koeffler HP.Human cathelicidin antimicrobial peptide(CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3.FASEB J,2005,19(9):1067-1077.
  • 9Wills-Karp M,Luyimbasi J,Xu X,et al.Interleukin-13:central mediator of allergic asthma.Science,1998,282(5397):2258-2261.
  • 10马雅心,戚好文.维生素D3联合地塞米松对哮喘大鼠的治疗作用及机制[J].第四军医大学学报,2008,29(15):1407-1409. 被引量:11

二级参考文献50

  • 1何皓頔,陈吉泉,修清玉.调节性T细胞在哮喘治疗中的新进展[J].国际呼吸杂志,2006,26(8):592-594. 被引量:2
  • 2王岷,吴大玮,王君,李西贵,孔春艳,曹爱芳.核因子κB和Th1/Th2细胞因子在哮喘小鼠发病中的变化及胸腺素、地塞米松干预作用的研究[J].国际呼吸杂志,2007,27(7):484-488. 被引量:4
  • 3全国儿童哮喘防治协作组.儿童哮喘的防治常规(试行方案)[J].中华儿科杂志,2004,42(2):100-104.
  • 4Hori S, Nomura T, Sakeguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science, 2003, 299:1057-1061.
  • 5Karagiannidis C, Akdis M, Holopainen P, et al. Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. J Allergy Clin Immunol, 2004,114 : 1425-1433.
  • 6Pin I, Gibson PG, Kolendowicz R, et al. Use of induced sputum cell count to investigate airway inflammation in asthma. Thorax, 1992,47:25-29.
  • 7Shimizu J, Yamazaki S, Takahashi T, et al. Stimulation ofCD4+ CD25+ regulatory T cell through GITR breaks immunological selftolerance. Nat Immunol, 2002,3 : 135-142.
  • 8Takahashi T, Tagami T, Yamazaki S, et al. Immunological selftolerance maintained by CD4+ CD25+ regulatory T cell constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med, 2000,192:303-310.
  • 9Wakkach A, Foumier N, Brun V, et al. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity, 2003,18:605-617.
  • 10Weiner HL. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory T cells. Immunol Rev, 2001,182:207-214.

共引文献74

同被引文献85

  • 1朱彦瑄,王颖,林虹.毛细支气管炎与营养性维生素D缺乏症[J].长春中医学院学报,1996,12(3):27-27. 被引量:3
  • 2MICHIGAMI T. Vitamin D metabolism and action[ J]. Clin Calci- um, 2007, 17(10) : 1493 -1498.
  • 3CARLOS C A Jr, RIFAS SHIMAN S L, LITONJUA A A, et al. Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3y of ageing. Am J Clin Nutr, 2007, 85 (3) : 788 - 795.
  • 4DEVEREUX G, LITONJUA A A, TURNER S W, et al. Maternal vitamin D intake during pregnancy and early childhood wheezing [J]. Am J Clin Nutr, 2007, 85(3) : 853 -859.
  • 5MANSBACH J M, CAMARGO C A Jr. Respiratory viruses in bronchiolitis and their link to recurrent wheezing and asthma [ J ]. Clin Lab Med, 2009, 29(4) : 741 -755.
  • 6BLACK P N, SCRAGG R. Relationship between serum 25 - hydroxyvitamin D and pulmonary function in the third national health and nutrition examination survey [ J ] Chest, 2005, 128 (6) : 3792 - 3798.
  • 7BOYAN B D, WONG K L, FANG M, et al. I alpha, 25(OH)2D3 is an autocrine regulator of extracellular matrix turnover and growth factor release via Erp60 activated matrix vesicle metalloproteinases [J]. J Steroid Biochem Mol Biol, 2007, 103(3/5) : 467 -472.
  • 8KOLI K, KESKI OJA J. Vitamin D3 regulation of transforming growth factor- beta system in epithelial and fibroblastic cells- relationships to plasminogen activation [ J ]. J Investig Dermatol Symp Proc, 1996, 1 (1) : 33 - 38.
  • 9SUTHERLAND E R, GOLEVA E, JACKSON L P, et al. Vitamin D levels, lung function, and steroid response in adult asthma[ J 3- Am J Respir Crit Care Med, 2010, 181(7) : 699 -704.
  • 10PIIPPO SAVOLAINEN E, REMES S, KANNISTO S, et al. Asth- ma and lung functions 20 years after wheezing in infancy: results from a prospective follow - up study [ J ]. Arch Pediatr Adnlesc Med, 2004, 158( 11 ) : 1070 - 1076.

引证文献7

二级引证文献44

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部