摘要
分泌蛋白质组包括了一个细胞分泌的所有基因产物.近年来,蛋白质组学技术和基因预测技术等的发展逐步揭示了其在病原体感染中的重要作用.病原体通过分泌蛋白质组抑制宿主的免疫系统、抵抗宿主酸性环境、营养掠夺等感染宿主和促进自身增殖.鉴定病原体的分泌蛋白质组有助于发现临床应用中新的药物作用靶点和生物标志物,辅助疾病的诊断与治疗.
Secretome includes all the gene products secreted by a cell. The development of proteomicbased approaches and genome-based computational prediction technology have gradually revealed secretome plays an important role in pathogen infection recently. Secretome facilitates pathogen to proliferate and invade the host by inhibiting the host＇s immune system, resisting acidic PH conditions, snatching nutrition and so on.Identification of pathogenic secretome helps discovering new drug targets and biomarkers, and supporting the diagnosis and treatment.
出处
《国际儿科学杂志》
2011年第1期18-21,共4页
International Journal of Pediatrics
基金
国家自然科学基金资助项目（30872798、81070004、81000765）
