女性内分泌调节轴功能对妊娠高凝状态影响

The Impact of Axial Function of Female Endocrine Adjustment upon the Pregnancy-related Hyper-coagulation

为观察女性内分泌调节轴即下丘脑-脑垂体-卵巢轴功能与妊娠后性激素水平间的相互作用及对妊娠高凝状态的影响．采用放免法测定了妊娠各期及脐静脉血睾酮（T）、雌二醇地（E2）、促卵泡生成素（FSH）、促黄体生成素（LH）、血检索B2（TXB2）、6-酮-前列环素（6－K－PGF1∞）。结果发现：妊娠使E2持续增高，刺激下丘脑GURH释放脉冲，导致雌激素强烈正反馈．促进了FSH、LH释做。高水平雌激素促发血小板花生四烯酸代谢紊乱，诱发妊娠期高凝状态。由于妊娠期高水平雌激素影响．使胎儿脐血中E2、FSH、LH亦处高水平。结果表明；下丘脑-脑垂体-卵巢轴在妊娠后变化使雌激素代谢产生一系列增高，并引起脐血相应的变化，是诱发妊娠期高凝状态及其症病的原因。脐血性激素水平及花生四烯酸含量异常．可能对新生儿血栓和出血性疾病诊断有意义。

To observe the interaction between the axial function of female endocrine adjustment and the pregnancy-related hormone 1evel. and its impact upon the pregnancy-related hypercoagulation, the radio-immunity therapeutic method was used to determine the content of T, E2, FSH, LH, TXB and 6-K -PGF1x during different stages of pregnancy and in tbe umbilical veins (the axis is formed by the lower tbalami-cerebral pituitary-gonad). The result is the finding that pregnancy continuously pushes up the E2 levwl, stimulates the releasps of pulses from the GURH of lower thalami, causes the strong positive feedback of female hormone and furthers the release of FSH and LH. A high level of female hormone gives rise to the metabolic disorder of arachidonic acid and the state of hyper-coagulation during pregnancy And because of the high level platelet of female hormone during pregnancy the E2. FSH and LH in the umbilical blood remains on the high level too. It now shows that the axis of lower thalami-cerebral pituitary-gonad causes the continual metabolic increase of female hormone during pregnancy and the corresponding changes in umbilical blood and is the cause of the state of hyper-coagulation and the related diseases. The abnormal level of sexual hormone in the umbilical blood and arachidonic acid may be meaningful in terms of the diagnosis of new-born thrombus and hemorrhagic diseases.