BRCA1和BRCA2在基底细胞样乳腺癌中的表达及意义

Expressions and clinical significance of BRAC1 and BRAC2 in basic-like breast cancer

目的:探讨BRCA1和BRCA2在基底细胞样型乳腺癌(BLBC)中的表达和相互关系。方法:采用免疫组化法(PV-9000法),检测86例BLBC癌旁组织和BLBC中BRCA1和BRCA2的表达,分析BLBC中BRCA1、BRCA2与临床病理因素间的关系及两者间相互关系。结果:(1)BRCA1在BLBC癌旁组织和BLBC中的表达分别95.3%和51.2%;BRCA2在BLBC癌旁组织及BLBC中的表达分别为96.5%和38.4%,差异有显著性(P<0.05)。(2)BRCA1在不同的年龄、绝经与否、肿块大小及复发和(或)远处转移的BLBC患者中的表达无明显差异(P>0.05),而在组织学分级、TNM分期,淋巴结转移情况不同的BLBC患者间的表达差异有显著性(P<0.05);BRCA2在不同的年龄、肿块大小、组织学分级、TNM分期、淋巴结转移情况及复发和(或)远处转移的BLBC患者间的表达无明显差异(P>0.05),在不同绝经情况的BLBC患者的表达差异有显著性(P<0.05)。(3)BLBC中BRCA1和BRCA2的阳性表达呈负相关(r=-0.234,P<0.05)。结论:BRCA1的和BRCA2在BLBC的发展中起一定的作用,并且BRCA1可作为判断BLBC预后的有效指标。

Objective To explore the expressions of BRACI and BRAC2 in basic-like breast cancer （BLBC） and their relationship. Methods The expressions of BRAC1 and BRAC2 were detected in 86 cases of BLBC tissues and its adjacent tissues by immunohistoehemistry. Their relationship with the elinieal pathological factors was analyzed. Results （1）The positive rate of BRAC1 was 95.3% and 51.2% in BLBC＇s adjacent tissues and BLBC tissues, respectively. The positive rate of BRAC2 was 96.5% and 38.4% in BLBC＇s adjacent tissues and BLBC tissues, respectively （P 〈 0.05）. （2） BRAC1 expressions were statistically different in patients with different histological grades, TNM grades and lymph node metastasis status （P 〈 0.05）. While not statistically different in differenl ages, postmenopause or not, tumor size, relapse and/or distant metastasis in BLBC patients （P 〉 0.05 ）.BRAC2 expressions were statistically different in postmenopause or not, while not statistically different in different age, tumor sizes, histological grades, TNM grades, lymph node metastasis status, relapse and/or distant metastasis （P 〉 0.05）. （3） BRCA1 expression was correlated with BRAC2expression （r = -0.234, P 〈 0.05）. Conclusion BRACl and BRAC2 might eontribule to the progression of BLBC, BRACI could be used as a potential marker for estimating the prognosis of BLBC.