摘要
为了提高大分子生物药经皮给药的治疗浓度,以多肽类生物药鲑降钙素为模型药物,研究离子导入法和化学促渗剂对鲑降钙素经皮渗透的影响。利用水平双室扩散池的方法,考察了离子导入法、化学促渗剂氮酮以及离子导入-氮酮并用对鲑降钙素经皮渗透的促渗作用。
To improve biological macromolecules transdermal therapeutic drug concentration,peptide drug salmon calcitonin is taken as a model of biological drugs,the impact of iontophoresis and chemical penetration enhancers on percutaneous penetration of salmon calcitonin is studied.Dual-chamber diffusion cells methods are adopted to investigate transdermal penetration effect of iontophoresis,Azone chemical penetration enhancers and iontophoresis-Azone and use of salmon calcitonin.
出处
《价值工程》
2011年第3期290-290,共1页
Value Engineering
关键词
离子导入
氮酮
鲑降钙素
经皮渗透
Iontophoresis
Azone
salmon calcitonin
transdermal
