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5(6)-羧基罗丹明110的合成工艺 被引量：1

Synthesis of 5(6)-carboxy-rhodamine 110
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摘要 研究了反应时间、升温方式、氮气保护等合成条件对5(6)-羧基罗丹明110合成反应的影响,并利用基质辅助激光解吸电离飞行时间质谱对5(6)-羧基罗丹明110的合成反应进行了检测。通过实验确定了较为适宜的合成条件:在氮气保护下80℃反应1h,然后在30min内匀速升温至180℃再反应6h。在此条件下反应基本完全,磺化物较少,且可以通过重结晶除去。产率可达93%。 The influence of some factors on synthesis of 5（6）-carboxy-rhodamine 110 was investigated,such as reaction time,heating mode,and nitrogen atmosphere.MALDI-TOF mass spectrometry was used for monitoring the synthesis reaction.The optimized reaction conditions are as follows.Under the protection of nitrogen,after reaction at 80℃ for 1 h the temperature is raised to 180℃ at a constant rate within 30 min.Then the reaction is maintained at the temperature for 6 h.Under the conditions the reaction is nearly completed.A little of sulfonated derivatives formed in the reaction can be purified by recrystallization.The yield is 93%.
作者 高勇 杨晓航 游楚楚 欧阳翰 袁耀锋
机构地区 福州大学化学化工学院 福建师范大学化学与材料学院 陕西中医学院医学技术系
出处 《化工学报》 EI CAS CSCD 北大核心 2011年第2期374-377,共4页 CIESC Journal
基金 福建省自然科学基金项目(2009J05023)~~
关键词 5(6)-羧基罗丹明110 基质辅助激光解吸电离飞行时间质谱 合成 5（6）-carboxy-rhodamine 110 MALDI-TOF mass spectrometry synthesis
分类号 O621.3 [理学—有机化学]
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化工学报
2011年 第2期

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