期刊文献+

消化系统肿瘤中miR-21研究进展

miR-21 in gastrointestinal cancer: research progresses
原文传递
导出
摘要 miRNA是广泛存在于真核生物的一种内源性的小分子RNA,作为一种关键因素与肿瘤的发生发展密切相关。miR-21是miRNA中具有代表性的基因,在多种肿瘤组织中过表达,这种一致的过表达提示miR-21基因有显著的致癌活性,在肿瘤中具有癌基因的功能。大量研究证实miR-21过表达可对消化道肿瘤的诊断、生物治疗和预后判断具有重要的指导意义。 miRNAs are endogenous short RNA molecules widely distributed in eukaryotic organisms. They are closely related to tumor development. One good example is miR-21. It is overexpressed in a variety of tumor tissues, suggesting that miR-21 may have significant carcinogenic activities and act as a oncogene. Many studies confirm that overexpression of miR-21 has great indication in the development, diagnosis, biological treatment and prognosis of gastrointestinal cancer.
出处 《国际肿瘤学杂志》 CAS 2011年第1期45-48,共4页 Journal of International Oncology
基金 浙江省自然科学基金资助项目(Y2091110) 卫生部科学研究基金一浙江省医药卫生重大科技计划基金资助项H(WKJ2010-2-004)
关键词 消化系统肿瘤 微RNAS Digestive system neoplasms MicroRNAs
  • 引文网络
  • 相关文献

参考文献2

二级参考文献65

  • 1Pillai RS. MicroRNA function: multiple mechanisms for a tiny RNA? RNA 2005; 11:1753-1761.
  • 2Zamore PD, Haley B. Ribo-gnome: the big world of small RNAs. Science 2005; 309:1519-1524.
  • 3Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-297.
  • 4Fitzgerald K. RNAi versus small molecules: different mechanisms and specificities can lead to different outcomes. Curr Opin Drug Discov Dev 2005, 8:557-566.
  • 5Brennecke J, Stark A, Russell R.B, Cohen SM. Principles of microRNA-target recognition. PLoS Biol.2005; 3:e85.
  • 6Croce CM, Calin GA. miRNAs, cancer, and stem cell division. Cell 2005; 122:6-7.
  • 7Chen CZ, Li L, Lodish HF, Bartel DE MicroRNAs modulate hematopoietic lineage differentiation. Science 2004; 303:83- 86.
  • 8Hwang HW, Mendell JT. MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 2006; 94:776-780.
  • 9Hammond SM. MicroRNAs as oncogenes. Curr Opin Genet Dev 2006; 16:4-9.
  • 10Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006; 6:259-269.

共引文献221

;
使用帮助 返回顶部