摘要
miRNA是广泛存在于真核生物的一种内源性的小分子RNA,作为一种关键因素与肿瘤的发生发展密切相关。miR-21是miRNA中具有代表性的基因,在多种肿瘤组织中过表达,这种一致的过表达提示miR-21基因有显著的致癌活性,在肿瘤中具有癌基因的功能。大量研究证实miR-21过表达可对消化道肿瘤的诊断、生物治疗和预后判断具有重要的指导意义。
miRNAs are endogenous short RNA molecules widely distributed in eukaryotic organisms. They are closely related to tumor development. One good example is miR-21. It is overexpressed in a variety of tumor tissues, suggesting that miR-21 may have significant carcinogenic activities and act as a oncogene. Many studies confirm that overexpression of miR-21 has great indication in the development, diagnosis, biological treatment and prognosis of gastrointestinal cancer.
出处
《国际肿瘤学杂志》
CAS
2011年第1期45-48,共4页
Journal of International Oncology
基金
浙江省自然科学基金资助项目(Y2091110)
卫生部科学研究基金一浙江省医药卫生重大科技计划基金资助项H(WKJ2010-2-004)