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SALL4基因在恶性血液病中的研究 被引量：1

SALL4 and hematologic neoplasms
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摘要 SALL4与造血系统恶性肿瘤的发生有密切关系。深入研究SALL4基因及蛋白的功能，将有助于阐明白血病的发病机制，为治疗白血病提供新靶点。 SALIA gene is closely related to body malformations related diseases, embryonic stem cell development, and hematopoietic malignancies. SALL4 can activate hematopoietic stem cell through Wnt signaling pathways, and promote continued proliferation of leukemia stem cells, leading to leukemia. In-depth study of SALL4 gene and its protein function will help clarify the pathogenesis of leukemia, providing a new target for the treatment of leukemia.
作者 喻依川 陈林
机构地区 重庆医科大学附属第二医院血液科
出处 《国际肿瘤学杂志》 CAS 2011年第1期64-66,共3页 Journal of International Oncology
基金 重庆市卫生局科研项目（2009-2-21）
关键词 基因 SALL4 肿瘤 白血病 干细胞 Genes, SALL4 Neoplasms Leukemia Stem cells
分类号 R733.7 [医药卫生—肿瘤]
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参考文献19

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  • 2Ma Y, Cui W, Yang J, et al. SALIA, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML intransgenicmice. Blood, 2008, 108 (8) :2726-2735.
  • 3De Celis JF, Barrio R. Regulation and function of Spalt proteins during animal development. Int J Dev Biol, 2009, 53 (8-11)) : 1385- 1398.
  • 4Cui W, Kong NR, Ma Y, et al. Differential expression of the novel oncogene,SALL4, in lymphoma, plasma cell mycloma, and acute lymphoblastic leukemia. Mod Pathol, 2006, 19(12): 1585-1592.
  • 5Liu A, Cheng L, Du J, Peng Y, et al. Diagnostic utility of novel stem cell markers SALIA, OCT4, NANOG, SOX2, UTF1, andTCL1 in primary mediastinal germ cell tumors. Am J Surg Pathol, 2010, 34 (5) : 697-706.
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同被引文献25

  • 1Rao S, Zhen S, Roumiantsev S, et al. Differential roles of Sall4 isoforms in embryonic stem cell pluripotency[ J ]. MolCell Biol,2010,30(22) :5364 -5380.
  • 2Zhang X, Yuan X, Zhu W, et al. SALL4 :An emerging cancer biomarker and target[ J]. Cancer Letters, 2014,357 (1) :55 - 62.
  • 3Choudhry Z, Rikani AA, Choudhry AM, et al. Sonic hedge- hog signalling pathway : a complex network [ J ]. Annu Rev Neurosci, 2014,21 ( 1 ) :28 - 31.
  • 4Yang J, Gao C, Chai L, et al. A novel SALL4/OCT4 tran- scriptional feedback network for pluripoteuey of embryonic stem cells [ J ]. PLoS One, 2010,5 ( 5 ) : el 0766.
  • 5Gao C, Kong NR, Chai L. The role of stem cell factor SALIA in leukemogenesis [ J ]. Crlt Rev Oncogenesls, 2011 , 16 ( 1/ 2) :117 - 127.
  • 6Ma Y, Cui W, Yang J, et al. SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenie mice [J]. Blood, 2006,108 ( 8 ) :2726 - 2735.
  • 7Lu J, Ma Y, Kong N,et al. Dissecting the role of SALIA, a newly identified stem cell factor, in chronic myelogenous leukemia[ J ]. Leukemia ,2011,25 ( 7 ) : 1211 - 1213.
  • 8Li A, Yang Y, Gao C, et al. A SALIA/ML[ZHOXA9 path- way in murine and human myelold leukemogenesis [ J ~. J Clin Invest,2013,123(10) :4195 -207.
  • 9Kobayashi D, Kuribayashi K, Tanaka M, et al. Overexpres- sion of SALIA- in lung cancer and its importance in cell proliferation [ J ]. Oncol Rep,2011,26 (d) : 965 - 970.
  • 10Kobayashi D, Kuribayshi K, Tanaka M, et al. SALIA is es- sential for cancer cell proliferation and is overexpressed at early clinical stages in breast cancer [ J i. Int J Oncol, 2011,38(4) :933 -939.

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国际肿瘤学杂志
2011年 第1期

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