甲羟戊酸通路对细胞生长调控作用的研究进展

Role of mevalonic acid pathway in the regulation of cell growth

甲羟戊酸(MVA)通路对细胞生长具有重要的调节作用,MVA及其衍生物通过对蛋白质异戊烯化和N糖基化修饰而影响Ras蛋白、生长因子及受体的功能、细胞内信号转导和细胞的生长。MVA通路参与血管活性物质生成的调节是其调节细胞生长的另一机制。MVA生成的限速酶羟甲基戊二酸单酰辅酶A(HMGCoA)则受MVA通路衍生物的反馈抑制。HMGCoA还原酶抑制剂通过抑制MVA及其衍生物的生成而抑制细胞的生长和增殖。

Mevalonic acid (MVA) pathway plays a key role in regulation of cell growth, MVA and derivatives effect the action of Ras protein, growth factor and receptor, intrac ellular signal transduction and cell growth through isopentenyl and N linked glycosylation modification on protein. Another mechanism of MVA pathway in regulation of cell growth is that affect production of vasoactive matter. Activity of 3 hydroxy 3 methylgutaryl coenzyme A (HMG CoA) reductase, limiting enzyme involved production of MVA, is inhibited by MVA pathway derivatives. HMG CoA reductase inhibitors could inhibit cell growth and proliferation through inhibiting production of MVA and derivatives.