眼镜蛇毒细胞毒素的抗肿瘤作用

Experimental Antitumor Effect of Cobra Venom Cytotoxin on Tumor bearing Mice

目的 研究眼镜蛇毒细胞毒素（ Ｃ Ｖ Ｃ Ｔ Ｘ）的体内抗肿瘤作用。方法 小鼠皮下、腹腔接种 Ｓ１８０ 、 Ｅ Ａ Ｃ后， 于接种部位注射不同剂量的 Ｃ Ｖ Ｃ Ｔ Ｘ， 每天 １ 次， 连续１０ 天， 观察瘤重抑制率和生命延长率。结果 适当剂量（０２～０８ｍ ｇ／ｋｇ） 的 Ｃ Ｖ Ｃ Ｔ Ｘ 能明显抑制肿瘤的生长 （ Ｐ＜ ００１），小鼠的存活时间明显延长（ Ｐ ＜ ００１）。结论 Ｃ Ｖ Ｃ Ｔ Ｘ 在小鼠体内对 Ｓ１８０ 、 Ｅ Ａ Ｃ有明显地抗肿瘤作用。

Objective To study the antitumor effect of cobra venom cytotoxin(CV CTX) on tumor bearing mice Methods After inoculation of S 180 ,EAC cells CV CTX was injected intraperitoneally into mice once per day for 10 days The tumor weight inhibition and the rates of life prolongation on mice with S 180 ,EAC were investigated Results Proper dose(0 2~0 8mg/kg) of CV CTX had inhibitive effect on tumor The tumor weight were significant decreased(P<0 01),the rates of life prolongation were increased than control(P<0 01) Conclutions CV CTX has antitumor effect on S 180 and EACin mice