2Cenac N,Andrews CN,Holzhausen M,et al.Role for protease activity in visceral pain in irritable bowel syndrome.J Clin Invest,2007,117:636-647.
3Reed DE,Barajas-Lopez C,Cottrell G,et al.Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons.J Physiol,2003,547:531-542.
4Coelho AM,Vergnolle N,Guiard B,et al.Proteinases and proteinase-activated receptor 2:a possible role to promote visceral hyperalgesia in rats.Gastroenterology,2002,122:1035-1047.
5Bouin M,Plourde V,Boivin M,et al.Rectal distention testing in patients with irritable bowel syndrome:sensitivity,specificity,and predictive values of pain sensory thresholds.Gastroenterology,2002,122:1771-1777.