摘要
肝细胞癌(HCC)是世界范围内发病率非常高的恶性肿瘤之一。HBV和HCV感染是肝细胞癌发生的主要致病因素。乙型肝炎病毒x蛋白(hepatitis B virus x protein,HBx)是HBV基因组x区编码的一种多功能蛋白,在肝细胞癌发生中起重要作用。HBV抗原表达可引起氧化应激(oxidative stress,OS)致DNA损伤(DNA damage)。研究发现DNA损伤反应的异常是肿瘤发生早期的重要机制。本文重点就HBx对DNA损伤反应的影响及这一影响作用与肝细胞癌发生关系的研究进展做一综述。
Hepatocellular carcinoma（HCC） is one of the most prevalent cancers worldwide.The main HCC-associated diseases are chronic infections with hepatitis B virus（HBV） and hepatitis C virus（HCV）.Hepatitis B virus x protein（HBx） encoded by X gene is a multifunctional protein which plays an important role in the pathogenesis of HCC.Expression of hepatitis B virus proteins can induce oxidative stress and thus lead to DNA damages.Previous studies have indicated that the disorder of DNA damage response is crucial to the early steps of carcinogenesis.In this review,we focus on the impact of HBx on DNA damage response and its role in HCC development.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2011年第1期77-80,共4页
Immunological Journal
