摘要
双磷酸盐已被证实具有抑制破骨细胞的分化,促进骨形成的作用。研究发现其可以抑制颌骨吸收,影响牙齿的萌出,牙根的形成和牙齿硬组织表面形态,实验还证实双磷酸盐可促使颌骨坏死。在将双磷酸盐应用到口腔疾病治疗的同时也出现了不良反应。本文就双磷酸盐在口腔医学的研究进展作一综述。
出处
《临床口腔医学杂志》
2011年第1期53-55,共3页
Journal of Clinical Stomatology
参考文献20
-
1Zahrowski JJ. Optimizing orthodontic treatment in patients taking bisphosphonates for osteoporosis [J]. Am J Orthod Dentofacial Orthop, 2009, 135 (3) : 361-374.
-
2Ezzat BA. Validity of prevention of glueoeortieoid-induced alveolar hone loss in rat by either calcitonin or alendronate administration [J]. Arch Oral Biol, 2010, 55 (10) : 788-796.
-
3Gao Y,Luo E,Hu J,et al. Effect of combined local treatment with zoledronic acid and basic fibroblast growth factor on implant fixation in ovariectomized rats [J]. Bone, 2009,44 (2) : 225-232.
-
4lchimura S. Bisphosphonate [J]. Clin Calcium, 2005,15 (4) :583- 590.
-
5Vitral RW, da Silva Campos MJ, de Andrade Vitral JC, et al. Orthodontic distalization with rigid plate fixation for anchorage after bone grafting and maxillary sinus lifting [J]. Am J Orthod Dentofacial Orthop, 2009, 136(1): 109-114.
-
6Abtahi J, Tengvall P, Aspenberg P. Bisphosphonate coating might improve fixation of dental implants in the maxilla: A pilot study [J]. Int J Oral Maxillofac Surg, 2010, 39 (7) : 673-677.
-
7孟海,郭艾.双磷酸盐对骨强度的影响[J].中国骨肿瘤骨病,2007,6(2):118-120. 被引量:6
-
8Weinstein RS,Roberson PK, Manolagas SC. Giant osteoclast formation and long-term oral bisphosphonate therapy [J]. N Engl J Med, 2009, 360 (1) : 53-62.
-
9Vieillard MH,Maes JM,Penel G,et al.Thirteen cases of jaw osteonecrosis in patients on bisphosphonate therapy [J]. Joint Bone Spine, 2008,75 (1) : 34-40.
-
10Ahundal H, Gtivener O. The effect of alendronate on resorption of the alveolar bone following tooth extraction [J]. Int J Oral Maxillofal Surg, 2004, 33 (3) : 286-293.
二级参考文献42
-
1夏维波.骨重建在维持骨强度中的意义[J].中华医学杂志,2006,86(6):363-365. 被引量:13
-
2[1]Reinholz G,Getz B,Pederson L,et al.Bisphosphonates directly regulate cell proliferation,differentiation,and gene expression in human osteoblasts.Cancer Res,2000,60:6001-6007.
-
3[2]Rogers M,Gordon S,Benford L,et al.Cellular and molecular mechanisms of action of bisphosphonates.Cancer,2000,88(suppl):2961-2978.
-
4[3]Rogers MJ.New insight into the molecular mechanisms of action of biosphosphonate.Curr Pharm Des,2003,9:2643-2658.
-
5[4]Mathov I,Plotkin L,Sgarlata C,et al.Extracellular signal regulated kinases and calcium channels are involved in the proliferative effect of bisphosphonates on osteoclastic cells in vitro.J Bone Miner Res,2001,16:2050-2056.
-
6[5]McClung M.Use of highly potent bisphosphonates in the treatment of osteoporosis.Curr Osteoporos Rep,2003,1:116-122.
-
7[6]Cremers SC,Pillai G,Papapoulos SE.Pharmacokinetics/pharmacodynamics of bisphosphonates:use for optimization of intermittent therapy for osteoporosis.Clin Pharmacokinet,2005,44:551-570.
-
8[7]Rubin CD,Emerging concepts in osteoporosis and bone strength.Curr Med Res Opin,2005,21:1049-1056.
-
9[8]Sone,T,Bone structure and bone quality.Clin Calcium,2005,15:925-930.
-
10[9]Turner CH,Biomechanics of bone deteminants of skeletal fragility and bone quality.Osteopros Int,2002,13:97-104.
共引文献8
-
1汤骏,金文姬,洪汝康,陈华.阿仑膦酸钠在伴骨质疏松症的老年髋部骨折中的应用[J].实用医学杂志,2009,25(8):1302-1304. 被引量:4
-
2阎丹,高宁.我院2006~2009年治疗恶性肿瘤骨转移药应用分析[J].中国药房,2010,21(14):1277-1279.
-
3胡昊,蔡林,金伟,张翼.弥漫性特发性骨肥厚一例报告[J].中国骨肿瘤骨病,2010,9(3):282-284.
-
4卢伟筠.60例慢性单纯性牙龈炎治疗观察[J].中国当代医药,2010,17(22):256-256. 被引量:5
-
5吴亚菲,赵蕾.牙周病药物治疗[J].中国实用口腔科杂志,2008,1(7):396-399. 被引量:9
-
6高克加,舒怡,肖梅芳,蔡瑾,梅小刚,叶智卫,张芬芳,朱吕佶,赵国定.不同双磷酸盐药物在联合“骨康灵”治疗中对股骨头坏死的疗效研究[J].中国骨质疏松杂志,2015,21(9):1038-1043. 被引量:1
-
7高克加,赵国定,梅小刚,叶智卫,蔡瑾,肖梅芳,舒怡,朱吕佶,张芬芳.骨康灵联合^(99)Tc-MDP干预股骨头坏死的实验研究[J].中华中医药学刊,2016,34(4):937-939. 被引量:1
-
8潘剑,王杞章,刘济远.双膦酸盐相关性颌骨坏死[J].华西口腔医学杂志,2017,35(1):29-36. 被引量:28
同被引文献34
-
1Drake MT, Clarke BL, Khosla S. Bisphosphonates: mechanism of action and role in clinical practice. Mayo Clin Proe, 2008, 83(9): 1032-1045.
-
2Cramer J, Gold D, Snverrnan S, et al. A systematic review oF persistence and compliance with bisphosphonates for osteoporosis. Osteoporosis Int, 2007, 18(8): 1023-1031.
-
3Bechmann G, Kriegman A, Goncalves J, et al. Effect of zoledronic acid compared with raloxifene on bone turnover markers in postm- enopausal women with low bone density. The North American Menopause Society, 2011, 18(8): 851-856.
-
4R? kel A, Boucher A, Georges L, et al. Role of zoledronic acid in the prevention and treatment of osteoporosis. Clinical Interventions in Aging, 2011, 6: 89-99.
-
5Amanat N, McDonald M, Godfrey C, et al. Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture re- pair. J Bone Miner Res, 2007, 22(6): 867-876.
-
6Yanik B, Bavbek N, Yanik T, et al. The effect of alendronate, risedronate, and raloxifone on renal functions, based on the Cock-eroft and Gau|t method, in postmenopausal women. Ren Fail, 2007, 29 (4) : 471.
-
7Hansen T, Kirkpatrick CJ, Waiter C, et ai. Increased numbers of osteoclasts expressing cysteine proteinase cathepsin K in patients with infected osteoradionecrosis and bisphosphonate : associated osteonecrosis : a paradoxical observation[J].Virchows Arch, 2006, 449(4):448-454.
-
8Kuroshima S, Go VA, Yamashita J. Increased numbers of nonattached osteoclasts after long-term zoledronic acid therapy in mice[J]. Endocrinology, 2012,153(1):17-28.
-
9Vigorita VJ, Silver JS, Eisemon EO. Osteoclast abnormalities in fractured bone during bisphosphonate treatment for osteoporosis: a case report[J].Skeletai Radiol, 2012, 41(7): 861-865.
-
10Hansen T, Kunkel M, Weber A, et al. Osteonecrosis of thejaws in patients treated with bisphosphonates-histomorphologic analysis in comparison with infected osteoradionecrosis[J].J Oral Pathol Med, 2006, 35(3):155-160.
引证文献3
-
1马俊华,刘念.唑来膦酸盐治疗绝经后骨质疏松症的疗效及不良反应[J].数理医药学杂志,2013,26(2):226-228. 被引量:5
-
2郎淼杰,周稚辉,毛静静,任曼曼,朱莉,王彦亮.唑来膦酸对血管内皮细胞损伤的影响[J].中华口腔医学杂志,2015,50(7):399-402. 被引量:4
-
3叶芝魁,张志明,崔琳娜,蒋校文.阿仑膦酸钠促进兔快速下颌骨牵张成骨的作用机制[J].中国组织工程研究,2024,28(23):3642-3647.
二级引证文献9
-
1赵钟文,郭燕芬,吴方真,吴宽裕,陈煜宇,朱敏.唑来膦酸注射液(密固达)治疗继发性骨质疏松症致下肢静脉血栓形成1例[J].风湿病与关节炎,2013,2(10):66-67. 被引量:2
-
2罗春晓,欧肇兰,朱燕,曹静娟,罗晓璇,黄师菊.水疗用于减轻唑来膦酸钠静脉滴注所致发热反应的护理体会[J].北方药学,2014,11(10):146-147. 被引量:2
-
3梅治,李青,袁元杏,张爱明,梁道臣,赵成毅.唑来膦酸治疗绝经后骨质疏松症的临床疗效分析[J].右江民族医学院学报,2015,37(3):411-412. 被引量:7
-
4史政康,蒋元斌,陈小微,计小东,郑红根,晋存.唑来膦酸治疗老年骨质疏松患者的临床疗效观察[J].中国继续医学教育,2016,8(17):187-189. 被引量:3
-
5王俊鹤.唑来磷酸钠治疗绝经后骨质疏松症的疗效分析[J].数理医药学杂志,2018,31(5):749-750. 被引量:2
-
6杨雪佳,胡靖,张媛媛,刘艳静,董秋立,李明芳.盐酸法舒地尔对PCI术后慢血流冠心病患者内皮细胞损伤的作用及其机制研究[J].中国现代医学杂志,2020,30(13):31-36. 被引量:14
-
7吴平凡,李羽,雷振革,陈林林.种植体引起双膦酸盐相关性下颌骨坏死1例[J].华西口腔医学杂志,2020,38(4):460-463. 被引量:3
-
8邱越桦,王海燕.富组蛋白1在基础研究中的研究进展[J].中国医药科学,2021,11(1):55-58. 被引量:1
-
9王一名,薛洋,赵吉宏,潘剑,邹多宏,崔念晖,张伟,王杞章,李志政,周驭穹,胡开进.漫步牙槽光辉岁月勇踏实践创新征途[J].中华口腔医学杂志,2024,59(4):301-311.
-
1盛璐,文建民,童昕.双磷酸盐相关性颌骨坏死1例报道及文献复习[J].广东牙病防治,2013,21(12):660-662. 被引量:5
-
2谢淑娟,占柳,潘卫红.唑来膦酸对颌骨骨质的不良反应及相关性研究进展[J].现代口腔医学杂志,2011,25(6):460-462. 被引量:1
-
3胡孔足,卜海富.长期应用双磷酸盐促进破骨细胞形成[J].临床骨科杂志,2009,12(2):162-162.
-
4黄如冰,吴晓林,俞娟.双磷酸盐相关性颌骨坏死12例临床分析[J].中华口腔医学研究杂志(电子版),2012,6(4):31-34. 被引量:16
-
5李志华.双磷酸盐对大鼠矢状缝快速扩开后骨缝重建的影响[J].国外医学(口腔医学分册),2003,30(2):118-118.
-
6杨便红.多发性骨髓瘤使用双磷酸盐引起颌骨坏死的探讨与护理[J].中华现代护理杂志,2009,15(15):1449-1450. 被引量:2
-
7谢淑娟,占柳,潘卫红.唑来膦酸对颌骨骨质的影响及相关性研究进展[J].华中科技大学学报(医学版),2012,41(1):122-126. 被引量:8
-
8黄伟,曾宪涛,冷卫东,赵吉宏,郭毅,李祖兵.双磷酸盐相关性颌骨坏死的循证治疗:附3例报道[J].中国口腔颌面外科杂志,2013,11(3):221-228. 被引量:7
-
9孙海燕,李欢,葛成.系统性疾病治疗与口腔病灶感染[J].中国微生态学杂志,2015,27(2):240-243. 被引量:2
-
10谢淑娟,占柳,潘卫红.唑来膦酸促进口腔种植体骨结合的研究现状[J].医学研究生学报,2012,25(1):76-79. 被引量:7