一维链状三环己基锡羧酸酯的合成、晶体结构及生物活性

The One-Dimensional Chain:Synthesis,Crystal Structure and Biological Activities of Tricyclohexyl Tin Carboxylates

本文以含酯基刚性一元酸L1H(8-乙氧羰基-1-萘甲酸)和含羰基柔性一元酸L2H(4-羰基-4-苯基丁酸)作为多齿配体,分别与三环己基氢氧化锡发生自组装反应,获得了2个新型三环己基锡羧酸酯配合物[(C6H11)3SnL1](1)和[(C6H11)3SnL2](2)(C6H11为环己基)。采用元素分析、1H NMR、FTIR及晶体结构测定等手段对配合物1和2进行了结构表征,在2个新配合物中,锡原子均为六配位,构成以锡原子为中心的扭曲单加帽三角双锥构型,并且通过O→Sn分子间配位键形成了一维超分子链。初步研究了杀菌活性和抗癌活性。

Two new supramolecular chains,namely [（R）3SnL1]（1） and [（R）3SnL2]（2）（where R=cyclohexyl,HL1=8-（ethoxycarbonyl）-1-naphthoic acid,HL2=4-cyclohexyl-4-oxobutanoic acid）,were synthesized by the self-assemble reaction of R3SnOH with the corresponding acids in a suitable mole ratios respectively.Complexes 1 and 2 were structurally characterized by elemental analyses,FTIR spectroscopy,1H NMR spectroscopy and single crystal X-ray diffraction analysis.The tin atom in complexes 1 and 2 adopts distorted monocapped trigonal bipyramidal geometry with six-coordinated,and exhibits a one-dimensional supramolecular chain through intermolecular O→ Sn interactions.The complexes 1 and 2 show antibiotic and anti-tumour activities in vitro experiments.CCDC：796811,1;796812,2.