牙周非手术治疗对重度牙周炎病人TNF-α和血管内皮功能的影响

The effect of non-surgical periodontal therapy on vascular endothelial function and tumor necrosis factor-α level in patients with severe periodontitis

目的:探讨牙周非手术治疗对重度牙周炎病人血管内皮功能和TNF-α水平的影响。方法:选择20名重度牙周炎病人,比较牙周非手术治疗前及治疗后3个月的出血指数、探诊深度、附着水平、菌斑指数、TNF-α、血流介导的肱动脉扩张和硝酸甘油介导的肱动脉扩张。结果:牙周非手术治疗后3个月,所有病人的牙周临床指标(探诊深度,附着丧失,出血指数和菌斑指数)均较治疗前有明显好转(P<0.05);TNF-α水平较治疗前明显下降(P<0.05);血流介导的肱动脉扩张率明显升高(P<0.05);而硝酸甘油介导的肱动脉扩张率变化不明显。结论:治疗牙周炎有助于改善血管内皮功能和降低TNF-α水平。

AIM： To investigate the effects of non-surgical periodontal therapy on vascular endothelial function and tumor necrosis factor-α levels in patients with severe periodontitis.METHODS：Twenty patients with severe periodontitis were selected.Sulcus bleeding index（BI）,probing depth（PD）,attachment loss（AL）,plaque index（PLI）,tumor necrosis factor-α（TNF-α）,flow mediated dilation（FMD） and nitroglycerin mediated dilation（NMD） were assessed respectively before and 3 months after non-surgical periodontal therapy.RESULTS：Three months after non-surgical periodontal therapy,all patients demonstrated significant improvement in clinical periodontal status including PD,AL,BI and PLI.TNF-α level was significantly decreased.FMD was increased.However,no difference was found in NMD.CONCLUSION：Non-surgical periodontal therapy can reduce TNF-α levels and improve vascular endothelial function,which might be helpful for decreasing the risk of coronary heart disease.