听觉事件相关电位技术在皮质下缺血性血管病变患者认知功能评估中的价值

The value of auditory event-related potentials in the assessment of cognitive function of patients with subcortical ischemic vascular disease

目的:观察皮质下缺血性血管病变(SIVD)中老年患者的事件相关电位(ERP)波形变化特点,探讨ERP技术对SIVD中老年患者认知功能的临床评估价值。方法:选取8例临床明确诊断为SIVD的卒中患者为SIVD组,记录其完成主动性听觉Oddball范式任务时的ERP波形,并行简易精神状态评估量表(MMSE)及蒙特利尔认知评估量表(MoCA)评估;选取8例性别年龄相匹配的健康被试为对照组,进行统计学分析。结果:与对照组相比,SIVD组额区导联N2复合波及N2b潜伏期明显延长,差异有显著性意义(P<0.05);MMSE及MoCA分值减低,但差异无显著性意义(P>0.05)。结论:SIVD损伤可能主要影响N2复合波的波形变化,故在评估此类患者的认知功能时,可以将N2复合波及N2b的潜伏期作为一种客观的观察指标。

Objective：To observe the abnormality of the long latency components and the subcomponents of N2 complex of auditory event-related potentials（ERPs） in the aged patients with subcortical ischemic vascular disease （SIVD）,and evaluate their values in assessing the cognitive function of SIVD. Method：The SIVD group included 8 patients clinically diagnosed with SIVD,and the control group included 8 healthy subjects whose sex and age matched with those in SIVD group. Their ERPs were recorded during an active auditory discrimination task of classic oddball paradigm. And then they were assessed by neuropsychological tests including minimental status examination（MMSE） and the Montreal cognitive assessment （MoCA）. Result：Compared with the controls,the latencies of N2 complex and N2b at FZ site were significantly longer in SIVD group （P0.05）,the scores of MMSE and MoCA slightly decreased but without significance. Conclusion：It＇s possibly seemed that the injury of SIVD mainly reduced the latency of N2 complex. So the latency of N2 complex and N2b might be chosen as an objective measurement in assessing the cognitive function of aged patients with SIVD.