皮肤肿瘤中Wnt／β-连环蛋白信号通路的研究进展

Wnt/β-catenin signaling pathway in cutaneous tumors： an update

Wnt／β-连环蛋自信号通路的异常活化常与皮肤肿瘤的发生发展密切相关。导致通路异常的因素较多，如分泌性Wnt蛋白失调；通路蛋白分子或旁路调控分子的突变；病毒感染和其他通路交叉影响等。通路的致瘤机制及对肿瘤的生物学影响还存在组织特异性，而皮肤肿瘤种类多，且组织来源广泛。因此探索Wnt通路在皮肤肿瘤中差异及组织特异性将对肿瘤靶向治疗研究有指导意义。

The abnormal activation of Wnt/β-catenin signaling pathway is usually and closely related to the occurrence and development of cutaneous tumors. There are various factors causing the abnormality of this pathway, such as deregulated expression of secreted Wnt protein, mutations of proteins involved in this pathway or regulatory molecules in bypass pathway, viral infection, interaction with other pathways, and so on. In addition, the tumorigenic mechanisms of this pathway and its biologcal effects on tumors are considered to be tissue-specific. However, the types and tissue origins of cutaneous tumors are various. Therefore, exploring the disparities and tissue specificity of Wnt pathway in cutaneous tumors will provide a guide to the targeted therapy of tumors.