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角化性皮肤病和炎症性皮肤病与屏障功能异常的关系

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摘要 角质层屏障由角质形成细胞（KC）和细胞间脂质构成，二者形成“砖-水泥”样的结构，即亲水的、富含纤维蛋白的KC（砖）被疏水的脂质双分子层状结构（水泥）所包绕。这种结构可以防止皮肤内的水分和电解质丢失，还可以抵御外界理化因素进入对皮肤的损伤。角质层在阻挡微生物入侵的同时，还有许多表皮抗菌肽可以使正常菌群繁殖的同时抑制致病微生物的生长。
作者 吴艳 陈璨 仲少敏 PeterMElias 茼茂强 朱学骏
机构地区 北京大学第一医院皮肤科 美国加州大学旧金山分校VA医学中心皮肤科
出处 《国际皮肤性病学杂志》 2011年第1期56-58,共3页 International Journal of Dermatology and Venereology
关键词 炎症性皮肤病 角化性皮肤病 功能异常 屏障 角质形成细胞 层状结构 致病微生物 纤维蛋白
分类号 R751 [医药卫生—皮肤病学与性病学]
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参考文献18

  • 1Elias PM, Hatano Y, Williams ML. Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms. J Allergy Clin Immunol, 2008, 121 (6): 1337-1343.
  • 2Bollag WB, Zhong X, Josephson S. 8-C1-Adenosine enhances 1,25-dihydmxyvitamin D3-induced growth inhibition without affecting 1,25-dihydroxyvitamin D3-stimulated differentiation of primary mouse epidermal keratinocytes. BMC Pharmacol, 2004, 4: 13.
  • 3Schmuth M, Gruber R, Elias PM, et al. Ichthyosis update: towards a function-driven model of pathogenesis of the disorders of cornification and the role of corneocyte proteins in these disorders. Adv Dermatol, 2007, 23:231-256.
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  • 10Hollox EJ, Huffmeier U, Zeeuwen PL, et al. Psoriasis is associat- ed with increased beta-defensin genomic copy number. Nat Genet, 2008, 40(1 ): 23-25.

二级参考文献10

  • 1Descargues P,Deraison C,Bonnart C,et al.Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity[J].Nat Genet,2005,37(1):56-65.
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  • 3Chavanas S,Bodemer C,Rochat A,et al.Mutations in SPINK5,encoding a serine protease inhibitor,cause Netherton syndrome[J].Nat Genet,2000,25(2):141-142.
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  • 10袁肖海,王学民.Netherton综合征1例[J].临床皮肤科杂志,2004,33(3):162-163. 被引量：5

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国际皮肤性病学杂志
2011年 第1期

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