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药物基因组学和个体化医学的转化研究进展 被引量:19

Translational approach for pharmacogenomics and personalized medicine
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摘要 遗传药理学和药物基因组学作为新兴领域,旨在促进个体化医学模式的早日实现。如何将遗传药理学和药物基因组学的实验研究成果转化为实际应用是目前最为重要和亟待解决的问题。本文将综述国际上遗传药理学和药物基因组学的研究成果在临床个体化治疗及新药开发领域的转化和应用的进展情况。 Pharmacogenetics and pharmacogenomics are promising fields that will enable personalized therapy.However,one of the most important issues to be conquered in the practice of personalized medicine is the translation of scientific discoveries into better therapeutic outcomes.The international pharmacogenetic and pharmacogenomic approaches made in the field of personalized medicine and drug discovery are summarized in this review.
作者 张伟 周宏灏
出处 《药学学报》 CAS CSCD 北大核心 2011年第1期1-5,9,共5页 Acta Pharmaceutica Sinica
基金 国家自然科学基金资助项目(30801421) 国家“重大新药创制”科技重大专项(2009ZX09501-032)
关键词 转化研究 遗传药理学 药物基因组学 个体化医学 translational research pharmacogenetics pharmacogenomics personalized medicine
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  • 1Auffray C, Charron D, Hood L. Predictive, preventive, personalized and participatory medicine: back to the future [J]. Genome Med, 2010, 2: 57.
  • 2Carrasco-Garrido P, de Andr6s LA, Barrera VH, et al. Trends of adverse drug reactions related-hospitalizations in Spain (2001-2006) [J]. BMC Health Serv Res, 2010, 10: 287.
  • 3Clayton TA, Lindon JC, Cloarec O, et al. Pharmacometabonomic phenotyping and personalized drug treatment [J]. Nature, 2006, 440: 1073-1077.
  • 4Amacher DE. Reactive intermediates and the pathogenesis of adverse drug reactions: the toxicology perspective [J]. Curr Drug Metab, 2006, 7: 219-229.
  • 5Little S. The impact of FDA guidance on pharmacogenomic data submissions on drug development [J]. IDrugs, 2005, 8: 648-650.
  • 6Giacomini KM, Brett CM, Altman RB, et al. The pharmaco- genetics research network: from SNP discovery to clinical drug response [J]. Clin Pharmacol Ther, 2007, 81: 328-345.
  • 7Thorn CF, Klein TE, Altman RB. PharmGKB: the pharmacogenetics and pharmacogenomics knowledge base [J]. Methods Mol Biol, 2005, 311: 179-191.
  • 8Cooper GM, Johnson JA, Langaee TY, et al. A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose [J]. Blood, 2008, 112: 1022- 1027.
  • 9Ndegwa S. Pharmacogenomics and warfarin therapy [J]. Issues Emerg Health Technol, 2007, (104): 1-8.
  • 10Gage BF, Lesko LJ. Pharmacogenetics of warfarin: regulatory, scientific, and clinical issues [J]. J Thromb Thrombolysis, 2008, 25: 45-51.

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