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作用于钾离子通道的抗心律失常药物的研发实例 被引量:2

The research practice of anti-arrhythmic agents targeting on potassium ion channel
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摘要 鉴于心律失常病因的复杂性,如何通过药物安全有效地控制心律失常疾病一直是亟待攻克的医药学难题。本文介绍了作用于钾离子通道的抗心律失常药物的研发实例,并对抗心律失常药物的研究现状进行了综述和展望。 Due to the complicated pathogenesis of cardiac arrhythmia,the safe and effective therapeutic strategies for cardiac arrhythmia remain an urgent medical problems in the recent years.In this paper,we introduced the research practice of anti-arrhythmic agents targeting on potassium ion channel.The research progress of anti-arrhythmic agents in up-to-date literatures were also reviewed and prospected.
出处 《药学学报》 CAS CSCD 北大核心 2011年第1期12-18,2,共7页 Acta Pharmaceutica Sinica
基金 国家"重大新药创制"科技重大专项(2009ZX09103-088) 国家高技术研究发展计划(863计划)资助项目(2007AA02Z307) 江苏省研究生科研创新计划资助项目(0275045)
关键词 抗心律失常药 钾离子通道 先导化合物 结构优化 anti-arrhythmic agent potassium ion channel lead compound structural modification
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  • 1余保瑞,龙超良,夏云峰,刘同库,汪海.哌芳安他对异丙肾上腺素诱发的小鼠心肌缺血的保护作用[J].中国临床药理学与治疗学,2004,9(6):637-640. 被引量:13
  • 2龚冬梅,邹晓龙,白云龙,单璐琛,孟庆新,于金玲,王绍婷,吕延杰,杨宝峰.哇巴因和乌头碱对豚鼠和大鼠心肌细胞钠电流的作用[J].哈尔滨医科大学学报,2006,40(5):347-350. 被引量:9
  • 3NATHAN PC, DAVID TL, WILLIAM JB, et al. Termination of drug-induced torsades de pointes with overdrive paeing[J]. Am J Emerg Med, 2010, 28(1): 95-102.
  • 4DU LP, LI MY, YANG Q, et al. Molecular hybridization, synthesis, and biological evaluation of novel chroman IKr and IKs dual blockers[ J ]. Bioorg Med Chem Lett, 2009, 19 ( 5 ) : 1477-1480.
  • 5GUO X, CHEN CL, YANG Q, et al. Effects of a novel class Ⅲ antiarrhythmic agent, CPUYll018, on rat atrial fibrillation[ J]. Drug Dev Res, 2010, 71(5) : 1-10.
  • 6CARLSSON L. The anaesthetised methoxamine-sensitised rabbit model of torsades de pointes [ J ]. Pharmacol Ther, 2008, 119 (2) : 160 -167.
  • 7MAZUR A, RODEN DM, ANDERSON ME. Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H8 prevents torsade de pointes in rabbits [ J]. Circulation, 1999, 100(24) : 2437 -2442.
  • 8Du L, Li M, Yang Q, et al. Molecular hybridization, synthesis, and biological evaluation of novel chroman I (Kr) and I (Ks) dual blockers [ J ]. Bioorg Med Chem Lett,2009,19(5 ) : 1477-1480.
  • 9Xu J, Yu P, Yang Q, et al. Antiarrhythmic efficacy of CPUY11018 under pathological conditions [ J ]. Drug Dev Res ,2013,74 (3) : 194-202.
  • 10Tang Y Q, Yu P, Zhao N, et al. The multiple ion channel blocker CPUYll018 prevents aconitine-induced arrhyth-miasIJ]. Drug Dev Res,2012,73( 4 ) :214-221.

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