摘要
鉴于心律失常病因的复杂性,如何通过药物安全有效地控制心律失常疾病一直是亟待攻克的医药学难题。本文介绍了作用于钾离子通道的抗心律失常药物的研发实例,并对抗心律失常药物的研究现状进行了综述和展望。
Due to the complicated pathogenesis of cardiac arrhythmia,the safe and effective therapeutic strategies for cardiac arrhythmia remain an urgent medical problems in the recent years.In this paper,we introduced the research practice of anti-arrhythmic agents targeting on potassium ion channel.The research progress of anti-arrhythmic agents in up-to-date literatures were also reviewed and prospected.
出处
《药学学报》
CAS
CSCD
北大核心
2011年第1期12-18,2,共7页
Acta Pharmaceutica Sinica
基金
国家"重大新药创制"科技重大专项(2009ZX09103-088)
国家高技术研究发展计划(863计划)资助项目(2007AA02Z307)
江苏省研究生科研创新计划资助项目(0275045)
关键词
抗心律失常药
钾离子通道
先导化合物
结构优化
anti-arrhythmic agent
potassium ion channel
lead compound
structural modification
