不同肥胖标准PCOS患者血清可溶性细胞间黏附分子-1水平比较

Comparative Study of Serum Soluble Intercellular Adhesion Molecule-1 in Different Obese Women with Polycystic Ovary Syndrome

目的:比较不同肥胖标准的多囊卵巢综合征(PCOS)患者血清可溶性细胞间黏附分子-1(sICAM-1)水平差异。方法:将PCOS患者以体质量指数(BMI)≥24kg/m2为肥胖标准分为肥胖A组和非肥胖A组,以腰臀比(WHR)≥0.8为肥胖标准,分为肥胖B组和非肥胖B组,以BMI≥24kg/m2且WHR≥0.8为肥胖标准分为肥胖C组和非肥胖C组,比较不同组别间的血清sICAM-1水平,并分析sICAM-1水平与BMI、WHR的相关性。结果:肥胖A、B、C组血清sICAM-1水平较对应的非肥胖A、B、C组显著升高(P<0.05);肥胖A、B、C3组之间血清sICAM-1的水平差异无统计学意义(P>0.05);非肥胖A组患者血清sICAM-1水平高于非肥胖B组、C组患者(均P<0.05),而非肥胖B、C组血清sICAM-1间差异无统计学意义(P>0.05);血清sICAM-1水平与BMI、WHR均呈正相关(r分别为0.204和0.360,均P<0.05)。结论:PCOS患者血清sICAM-1水平与肥胖有密切联系,PCOS患者sICAM-1水平随着WHR及BMI增大而升高。

Objective：To study the level of serum soluble intercellular adhesion molecule-1（sICAM-1） in obese women with polycystic ovary syndrome （PCOS）. Methods： The obese patients with PCOS were divided into two groups （obese A group and non-obese A group） according to the standard of body mass index （BMI） ≥ 24 kg/m2. The patients were divided into two groups （obese B group and non-obese B group） according to the standard of waist-hip ratio （WHR） ≥ 0.8. The patients were also divided into two groups（obese C groups and non-obese C group） according to the standard of BMI≥ 24 kg/m2 and WHR≥ 0.8. The serum levels of sICAM-1 were compared between groups. The correlation was analysed between the level of sICAM-1 and the values of BMI and WHR. Results：The serum levels of sICAM-1 were significantly higher in obese A, obese B and obese C groups than those of non-obese A, non-obese B and non-obese C groups （P 0.05）. There were no significant differences in serum levels of sICAM-1 between obese A, obese B and obese C groups （P 0.05）.The serum level of sICAM-1 was significant higher in non-obese A group than that of non-obese B group and non-obese C group （P 0.05）.But there was no significant difference in serum level of sICAM-1 between the patients of non-obese B group and non-obese C group （P 0.05）.There was a positive correlation between the serum level of sICAM-1,BMI and WHR（P 0.05）. Conclusion：There was a close correlation between the serum level of sICAM-1 and the obesity in patients with PCOS. The level of sICAM-1 increased with the increase in WHR and BMI in patients with PCOS.