主动脉外气囊隔膜泵心脏辅助装置的动物实验

The cardiac assistant effect of extra-aortic balloon pump on animals

目的 探讨主动脉外气囊隔膜泵心脏辅助治疗对心肌梗死后犬的影响,观察主动脉外反向搏动辅助的有效性及可行性.方法 结扎冠状动脉左前降支制作急性心肌梗死心衰动物模型12只,随机分为辅助组和对照组各6只.观察心肌梗死后两组动物1～6 h血流动力学指标、梗死面积和血液形态学等指标变化.结果 辅助组6只犬全部存活,对照组死亡3只（50%）.辅助组经反搏辅助后平均压,心输出量,心指数优于对照组（P＜0.05）,但对血细胞有破坏.结论 主动脉外气囊隔膜泵反向搏动心脏辅助能显著地改善心肌梗死动物血流动力学,减少死亡,破坏血细胞是其不足之处.

Objective The aim of this study was to determine the effect of a new method of cardiac assistant therapy with an extra-aortic balloon pump on the experimental dogs in which myocardial ischemia or infarction were induced, and to ob serve its effectiveness and feasibility. Methods Twelve animal models of myocardia 1 infarction were established with the method of left anterior descending coronary artery ligation. They were divided randomly into two groups, six in the experimental group and six in the untreated group. The end points observed were the differences between the two groups in the blood pressure, cardiac function, myocardial enzymes, infarction size and routine blood variables before procedure, 1,2, 3, 4, 5 and 6 hours after myocardial infarction. Results All six dogs in the experimental group were survived, with a mortality rate of 0.The number of death in the control group was three, with a mortality rate of 50%. Measurements such as mean blood pressure,cardiac output, cardiac index in the experimental group were better than those in the control group （ P 〈 0.05 ）. Mean heart rate before myocardial infarction in the experimental group was 156 beats per minute, as compared with 148 beats per minute in the control group, and was 128 vs. 67 beats per minute respectively six hours after myocardial infarction. The cardiac output was 3.48 vs. 4.98 liters per minute before myocardial infarction and was 6.10 vs. 0.85 liters per minute six hours after myocardial infarction. The average pressure was 94 mm Hg vs. 99 mm Hg before myocardial infarction and was 70 mm Hg vs. 33 mm Hg six hours after myocardial infarction. Conclusion The extra-aortic balloon pump significantly improved the hemodynamic variables of the experimental animals after myocardial infarction and reduced mortality. Injury to the blood cells may be the potential disadvantage.