期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

基于模型的耳蜗核反应特性研究 被引量：3

Response properties of cochlear nucleus neurons: a digital model-based study
下载PDF
导出
摘要 目的耳蜗核内的信息处理,是中枢对听觉信息处理的最先一环。根据神经元对短纯音刺激反应的时间特性来分类,耳蜗核神经元可以分为多种反应类型。我们用模型的方法来探讨这些不同反应类型的机制。方法基于Matlab7.0平台,在经典的积分-放电模型基础上构建时间编码模型。结果模型通过改变与神经元特性有关的参数可以很好的模拟耳蜗核中初级反应型、梳状型、给声开始型和建立型神经元。结论耳蜗核神经元反应特性主要是由神经元本身的特性决定。模型仿真结果与文献十分吻合,为后续研究听觉系统的作用机制打下基础。 Objective To investigate the mechanisms of different response patterns of the cochlear nucleus neurons based on a digital model. Methods Based on the platform of Matlab7.0 and the integrate-and-fire model, we constructed the temporal coding model.
作者 徐月晋 周凌宏 肖中举
机构地区 南方医科大学生物医学工程学院 基础医学院
出处 《南方医科大学学报》 CAS CSCD 北大核心 2011年第1期77-81,共5页 Journal of Southern Medical University
基金 国家自然科学基金(30730039,30970982)~~
关键词 耳蜗核 时间编码 积分 放电模型 cochlear nucleus temporal coding integrate-and-fire model
分类号 R764 [医药卫生—耳鼻咽喉科]
  • 相关文献

参考文献20

  • 1Palombi PS, Caspary DM. GABAA receptor antagonist bicuculline alters response properties of posteroventral cochlear nucleus neurons[J]. J Neurophysiol, 1992, 67(3): 738-46.
  • 2Evans EF, Zhao W. Varieties of inhibition in the processing and control of processing in the mammalian cochlear nucleus [ J ]. Prog Brain Res, 1993, 97: 117-26.
  • 3Rhode WS, Greenberg S. Lateral suppression and inhibition in the cochlear nucleus of the cat [J]. J Neurophysiol, 1994, 71(2): 493-514.
  • 4Caspary DM, Backoff PM, Finlayson PG, et al. Inhibitory inputs modulate discharge rate within frequency receptive fields of anteroventral cochlear nucleus neurons [J]. J Neurophysiol, 1994, 72(5): 2124-33.
  • 5Paolini AG, Clarey JC, Needham K, et al. Balanced inhibition and excitation underlies spike firing regularity in ventral cochlear nucleus chopper neurons[J]. Eur J Neurosci, 2005, 21(5): 1236-48.
  • 6Gai Y, Carney LH. Influence of inhibitory inputs on rate and timing of responses in the anteroventral cochlear nucleus [J]. J Neurophysiol, 2008, 99(3): 1077-95.
  • 7Rhode WS, Greenberg S. Physiology of the cochlear nucleus [M ]// Popper AN, Fay RR. The mammalian auditory pathway: neurophysiology. New York: Springer Verlag, 1992, 94-152.
  • 8Pfeiffer RR. Classification of response patterns of spike discharges for units in the cochlear nucleus: tone-burst stimulation [J]. Exp Brain Res, 1966, 1(3): 220-35.
  • 9Samson FK, Clarey JC, Barone P, et al. Effects of ear plugging on single-unit azimuth sensitivity in cat primary auditory cortex. I. Evidence for monaural directional cues. [J]. J Neurophysiol, 1993, 70(2): 492-511.
  • 10Zurita P, Villa AE, de Ribaupierre Y, et al. Changes of single unit activity in the cat's auditory thalamus and cortex associated to different anesthetic conditions [J]. Neurosci Res, 1994, 19(3): 303-16.

同被引文献16

  • 1Zeng FG, Rebscher S, Harrison W, et al. Cochlear implants: system design, integration, and evaluation [J]. IEEE Rev Biomed Eng, 2008, 1: 115-42.
  • 2Vandali AE, van Hoesel R. A portable programmable digital sound processor for cochlear implant research [J]. IEEE Transa Rehabil Eng, 1993, 1(2): 94-100.
  • 3Morris LR, Barszczewski P. Algorithm s, hardware, and software for a digital signal processor microcomputer-based speech processor in a multielectrode cochlear implant system [J]. IEEE Trans Biomed Eng, 1989, 36(6): 573-84.
  • 4Blamey PJ, Dowell RC, Clark GM, et al. Acoustic parameters measured by a formant-estimating speech processor for a multiple- channel cochlear implant[J]. J Acoust Soc Am, 1987, 82(1): 38-47.
  • 5蒋涛,曾凡钢.听觉科学概论[M].北京:中国科学技术出版社,2005:177-200.
  • 6Clark GM. Cochlear implants:future research directions [J]. Ann Otol Rhinol Laryngnl, 1995, 104(suppl.166): 22-27.
  • 7Clark GM. Cochlear implants: climbing new mountains the Graham Fraser memorial lecture 2001 [J]. Cochlear Implants Int, 2001, 2(2): 75-97.
  • 8Vermeire K, Anderson I, Flynn M, et al. The influence of different speech processor and hearing aid settings on speech perception outcomes in electric acoustic stimulation patients [J]. Ear Hear, 2008, 29(1): 76-86.
  • 9Luo X, Fu Q J, Wei CG, et al. Speech recognition and temporal amplitude modulation processing by Mandarin-speaking cochlear implant users[J]. Ear Hear, 2008, 29(6): 957-70.
  • 10Sit JJ, Simonson AM, Oxenharn A J, et al. A low-power asynchronous interleaved sampling algorithm for cochlear implants that encodes envelope and phase information[J]. IEEE Trans Biomed Eng, 2007, 54(1): 138-49.

引证文献3

二级引证文献2

南方医科大学学报
2011年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部