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前列腺癌中血管内皮生长因子-C、血管内皮生长因子受体-3的表达与病理分级的相关性 被引量：4

Correlation of the expressions of VEGF-C and VEGFR-3 to the pathological grade of prostate cancer
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摘要 目的探讨血管内皮生长因子-C(VEGF-C)、血管内皮生长因子受体3(VEGFR-3)在前列腺癌(Pca)组织中的表达与肿瘤病理分级的关系。方法采用ElivisionTM Plus二步法检测Pca组织中VEGF-C、VEGFR-3的表达情况。结果在25例前列腺癌组织中,VEGF-C表达阳性率为80%,VEGFR-3表达阳性率为76%。Ⅰ组:Gleason评分≥6分的19例,Ⅱ组:Gleason评分大于4分但小于6分的6例,VEGF-C的表达阳性率分别为94.7%、33.3%,P<0.01,组间差别有显著性意义。VEGFR-3的表达阳性率分别为89.5%、33.3%,P<0.05,组间差别有显著性意义。VEGF-C在前列腺癌组织中的表达水平与Gleason评分相关(R=0.436,P<0.05)。VEGFR-3在前列腺癌组织中的表达水平与Gleason评分显著相关(R=0.608,P<0.01)。VEGF-C、VEGFR-3在前列腺癌组织中的表达水平与年龄、PSA、前列腺体积无关,P>0.05。结论在Gleason评分大于4分的Pca组织中,VEGF-C、VEGFR-3的表达水平与Gleason分级密切相关,VEGF-C、VEGFR-3的表达强度可作为前列腺癌恶性程度的判断指标之一。 Objective To investigate the correlation of the expression of VEGF-C and VEGFR-3 to the pathological grade of human prostate cancer. Methods Immunohistochemistry was used to detect the expression of VEGF-C and VEGFR-3 in 25 cases of prostate cancer tissues.
作者 陈虎 赵国平 肖宁新 夏强 赖建生 郑东升 赵振华 辛玉宏
机构地区 南方医科大学附属江门医院泌尿外科 病理科
出处 《南方医科大学学报》 CAS CSCD 北大核心 2011年第1期155-159,共5页 Journal of Southern Medical University
基金 江门市科技计划项目(A2008129)
关键词 前列腺癌 血管内皮生长因子-C 血管内皮生长因子受体3 GLEASON评分 prostate cancer VEGF-C VEGFR-3 Gleason score
分类号 R737.25 [医药卫生—肿瘤]
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参考文献10

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共引文献24

同被引文献42

  • 1周洪澜,邢春伟,葛岩,王心蕊,王医术.前列腺癌中基质金属蛋白酶7,9的表达及其与VEGF的关系[J].中国老年学杂志,2007,27(14):1385-1387. 被引量：8
  • 2Semenza GL. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med ,2002,8 (4 Suppl) : S62-67.
  • 3Mabjeesh NJ, Willard MT, Frederickson CE, et al. Androgens stim- ulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein ki- nase B in prostate cancer cells. Clin Cancer Res, 2003,9 ( 7 ) : 2416-2425.
  • 4Lebdai S, Bigot P, Azzouzi AR. High-grade prostate cancer and fi- nasteride. BJU Int ,2010,105 (4) :456-459.
  • 5Reed AB, Parekh DJ. The utility of 5-alpha reductase inhibitors in the prevention and diagnosis of prostate cancer. Curt Opin Urol, 2009,19 (3) :238-242.
  • 6Kaplan SA, Roehrbonl CG, Meehan AG, et al. PCPT: Evidence that finasteride reduces risk of most frequently detected intermediate and high grade ( Gleason score 6 and 7 ) cancer. Urology, 2009,73 (5) :935-939.
  • 7JacquesFerlay,Hai‐RimShin,FreddieBray,DavidForman,ColinMathers,Donald MaxwellParkin.Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008[J]. Int. J. Cancer . 2010 (12)
  • 8Liang‐Xi Xie,Tian‐Tian Zhai,Li‐Ping Yang,Eleanor Yang,Xiao‐Hui Zhang,Jiong‐Yu Chen,Hao Zhang.Lymphangiogenesis and Prognostic Significance of Vascular Endothelial Growth Factor C in Gastro‐oesophageal Junction Adenocarcinoma[J]. Int. J. Exp. Path. . 2013 (1)
  • 9Tian‐BaoWANG,JinWANG,Xiu‐QingWEI,BoWEI,Wen‐GuangDONG.Serum vascular endothelial growth factor‐C combined with multi‐detector CT in the preoperative diagnosis of lymph node metastasis of gastric cancer[J]. Asia‐Pacific Journal of Clinical Oncology . 2012 (2)
  • 10HuidongLiu,YanmeiYang,JianbingXiao,YanhongLv,YanLiu,HuikeYang,LinghuiZhao.COX‐2‐Mediated Regulation of VEGF‐C in Association With Lymphangiogenesis and Lymph Node Metastasis in Lung Cancer[J]. Anat Rec . 2010 (11)

引证文献4

二级引证文献27

南方医科大学学报
2011年 第1期

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