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NPM基因突变在血液肿瘤中的作用 被引量：4

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摘要 NPM是一种主要定位于核仁并可在核仁与胞浆之间穿梭的核磷酸蛋白.NPM1基因异常最初是在急性髓细胞白血病（AML）患者中被发现;大约三分之一的原发性AML患者中存在NPM1基因突变,65%核型正常的AML患者具有NPM1突变特征,少数骨髓增生异常综合征患者中也发现NPM1基因突变.NPM1基因突变是完全缓解、无复发生存和无变故生存的有利预后因素.NPM1基因突变在整个疾病期都非常稳定,可作为AMI微小残留病灶检测的标记物;NPM1突变为白血病的靶向治疗提供了前景.本文对NPM1基因突变与血液肿瘤的关系及发生机制进行综述.
作者 李凯敏(综述) 郝洪岭(审校)
机构地区 河北省人民医院血液科
出处 《国际输血及血液学杂志》 CAS 2011年第1期79-82,共4页 International Journal of Blood Transfusion and Hematology
关键词 核磷酸蛋白 急性髓细胞向血病 骨髓增生异常综合征 基因突变
分类号 R734.2 [医药卫生—肿瘤]
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参考文献25

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二级参考文献10

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共引文献9

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二级引证文献15

国际输血及血液学杂志
2011年 第1期

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