上海市绝经后妇女冬季维生素D状况

Vitamin D status of Shanghai postmenopausal women in winter

目的调查上海市绝经后妇女在冬季(12月份)维生素D的状况。方法在社区101例年龄63.7±7.0岁健康绝经后妇女中,检测血清25羟维生素D[25(OH)D]、甲状旁腺激素(PTH),同时检测血钙、磷、碱性磷酸酶、肝肾功能及空腹血糖。所有研究对象均用双能X线吸收仪检测腰椎和股骨近端骨密度(BMD),同时用问卷调查生活方式。结果本研究101例绝经后女性血清25(OH)D平均值为17.09 ng/ml,PTH平均值51.0 pg/ml,维生素D缺乏者占(<20 ng/ml)68%,维生素D不足者(20～29 ng/ml)占了30%,只有2例维生素D充足(>30 ng/ml)占2%。PTH均值在维生素D缺乏组中(53.7 pg/ml)高于维生素D不足组(44.8 pg/ml),有统计学差异(P<0.05);但未发现血清25(OH)D与PTH有线性回归关系。同时未发现血清25(OH)D与血钙、BMD或BMI相关。结论上海市健康绝经后妇女在冬季维生素D普遍不足,维生素D缺乏组的PTH显著高于维生素D不足组,不良的生活方式及低维生素D和钙的摄入应引起重视。

Objective We aimed to describe the vitamin D status of Shanghai postmenopausal women in winter （December）. Methods Serum 25-hydroxyvitamin D and parathyroid hormone （PTH） , as well as serum calcium, phosphorus, alkaline phosphatase, hepatic and renal function, and fasting blood-glucose, were examined in 101 healthy postmenopausal women aged 63.7 ± 7.0 years in average. Bone mineral densities （BMDs） of the lumbar spine and the proximal femur were measured using dual-energy X-ray absorptiometry in all the women. All subjects were asked for life style with a questionnaire. Results The mean values of serum 25-hydroxyvitamin D and PTH were 17.09 ng/ml and 51.0 pg/ml, respectively. Among our subjects, the incidence of vitamin D deficiency （ 〈 20 ng/ml） was 68%. The incidence of vitamin D insufficiency （20-30 ng/ml） was 30%. Sufficient vitamin D status （ 〉 30 ng/ml） was only account for2% （in 2 women）. Mean values of PTH were higher （53.7 pg/ml） in vitamin D deficiency group than those in vitamin D insufficiency group （44. 8 pg/ml） , with statistical difference （ P 〈 0.05 ）. However, there was no linear correlation between 25-hydroxyvitamin D and PTH. No correlations were found between 25-hydroxyvitamin D and calcium, and between BMI and BMD. Conclusion Vitamin D deficiency is very common in postmenopausal women living in Shanghai in winter. PTH in vitamin D deficiency group was significantly higher than that in vitamin D insufficiency group. Unhealthy lifestyle and low calcium and vitamin D intakes should be taken into account.