局部晚期宫颈癌同步放化疗后巩固化疗的疗效分析

Analysis of curative effect of consolidation chemotherapy after concurrent chemoradiotherapy for locally advanced cervial cancer

目的探讨局部晚期宫颈癌同步放化疗后巩固化疗的疗效和毒副作用。方法将福州军区总医院2006年1月至2007年3月收治的78例局部晚期宫颈癌同步放化疗的患者随机分为巩固化疗组(40例)和观察组(38例),对比其3年生存率和毒副反应。结果巩固化疗组和观察组相比,3年生存率(87.5%和84.2%)和无进展生存率(80.0%和76.3%)均有所提高,但差异无统计学意义。巩固化疗组Ⅲ～Ⅳ度骨髓抑制发生率高于观察组(P<0.05)。结论局部晚期宫颈癌同步放化疗后巩固化疗对生存率有益,但骨髓抑制较为严重。

Objective To analyze the curative effect and toxicity of consolidation chemotherapy after concurrent chemoradiotherapy for locally advanced cervical cancer.Methods seventy-eight patients with locally advanced cervical cancer after concurrent chemoradiotherapy were randomly divided into consolidation group （40 cases） and control group （38 cases）. The survival rates and toxicity of the two groups were compared.Results The 3-year progression-free survival （PFS） rate of consolidation group and control group were 80.0% and 76.3% and the 3-year overall survival （OS） rate were 87.5% and 84.2%. The PFS and Os of consolidation group was longer than that of control group,but no signifcant differences.was found between these two groups （P0.05）. Ⅲ～Ⅳ degree myelosuppression occurred more frequently in the consolidation group than in control group （P0.05）.ConclusionThe DFS and OS of consolidation chemotherapy after concurrent chemoradiotherapy for locally advanced cervical cancer were longer than that of control group,but it has severer marrow toxicity.