高度近视儿童中未检测到TIGR基因突变(英文)

Lack of association between the TIGR gene mutation and the high myopia in Chinese children

目的:在具有家族史的高度近视儿童中进行TIGR基因突变筛查。方法:对高度近视儿童中TIGR基因第三外显子进行毛细血管电泳测序检测,并对结果进行序列分析。结果:在近视组和对照组中均未发现TIGR基因突变。结论:未能发现TIGR基因突变与高度近视相关证据。

AIM：To screen TIGR/myocilin gene（MYOC） mutation in high myopic Chinese children with family history.METHODS：Gene sequencing was performed in exon 3 of the TIGR gene in high myopic Chinese Children.The coding sequence of TIGR exon 3 was screened by capillary electrophoresis sequencing.The sequence alterations were analyzed by bioinformatics.RESULTS：TIGR gene mutation was not found in high myopic patients and normal controls group.CONCLUSION：No identified gene mutation is found in TIGR gene in high myopic Chinese children.