臭氧联合胶原酶注射与单纯臭氧治疗腰椎间盘突出症的疗效观察

Combined use of ozone and collagenase injection for the treatment of lumbar disc herniation:comparison of therapeutic efficacy with simple ozone injection

目的观察臭氧联合胶原酶注射治疗腰椎间盘突出症(LDH)与单纯臭氧治疗椎间盘突出症的不同疗效。方法在DSA导向下,正侧位透视后准确定位,采用9号穿刺针经皮穿刺向椎间盘内单纯注射臭氧或先后注射臭氧及胶原酶治疗76例腰椎间盘突出患者。结果治疗后1、3和6个月进行随访。1个月后随访,臭氧联合胶原酶注射治疗组(A组,38例)有效率为89.5%,单纯臭氧注射治疗组(B组,38例)有效率为86.8%;3个月后随访,A组有效率为92.1%,B组有效率为84.2%;6个月后随访,A组有效率为94.7%,B组有效率为81.6%。结论臭氧联合胶原酶注射治疗椎间盘突出症较单纯臭氧注射治疗椎间盘突出症,疗效更加显著,且中远期疗效更稳定。

Objective To observe the therapeutic effects of combined use of ozone and collagenase injection in treating lumbar disc herniation and to make a comparison of therapeutic efficacy with simple ozone injection.Methods Under DSA guidance,percutaneous puncturing of diseased lumbar disk with a gauge 9 needle was performed in 76 patient with lumbar disc herniation.After the needle position was confirmed in the right site simple ozone injection（control group,n=38） or combined use of ozone and collagenase injection（study group,n=38） was carried outs.The clinical results were evaluated and compared between two groups.Results After the treatment,all 76 patients were followed up regularly at 1,3 and 6 months.At 1,3 and 6 months after the therapy,the effective rate of study group was 89.5%,92.1% and 94.7% respectively,while the effective rate of control group was 86.8%,84.2% and 81.6% respectively.Conclusion For the treatment of lumbar disc herniation,the therapeutic effect of combined use of ozone and collagenase injection is much better than that by using simple ozone injection,moreover,it carries a quite stable long-term efficacy.