P-选择素与动脉内支架置入术后的再狭窄

The relationship between P-selectin and intra-arterial restenosis after stenting

血管内介入治疗常遇到的问题是血管内皮损伤、血栓形成和内膜增生所致的管腔再狭窄。在此过程中,细胞黏附分子(CAMs)可能起到重要作用,P-选择素是黏附分子选择素家族的重要成员,它主要表达在活化的血小板/内皮细胞表面,通过启动细胞初始黏附,并参与血管内介入治疗后早期炎症及管壁重构过程。

In endovascular interventional treatment the problem commonly encountered is the arterial restenosis due to vascular endothelial injury,thrombosis and intimal hyperplasia.In the process of arterial intimal hyperplasia,cell adhesion molecules may play an important role.The P-selectin,which is a significant element in adhesion molecules selectin family,is mainly expressed on the activated platelet and endothelial cell surface,and through starting cellular initial adhesion it is involved in early inflammation and wall reconstruction process after endovascular interventional treatment.