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Rad51与肿瘤关系的研究进展 被引量：9

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摘要 Rad51基因作为DNA修复基因,对维持基因的稳定性起着关键性的作用。Rad51基因的突变在多种肿瘤的发生、发展过程中起着重要作用。肿瘤对放疗和化疗药物的耐药性也与Rad51基因的突变相关。另外,Rad51基因可能与其它基因相互作用,共同影响肿瘤的发生、发展。该文对近年来该领域的研究进展作一综述。
作者 彭亚婷 梅金红
机构地区 南昌大学第一附属医院病理科
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2011年第1期86-89,共4页 Chinese Journal of Clinical and Experimental Pathology
关键词 RAD51 肿瘤 同源重组 文献综述
分类号 R73 [医药卫生—肿瘤] R341 [医药卫生—基础医学]
  • 相关文献

参考文献34

  • 1Liu Y,Masson J Y,Shah R,et al.RAD51C is required for Holliday junction processing in mammalian cells[J].Science,2004,303:243-6.
  • 2Richardson C,Stark J M,Ommundsen M,et al.Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability[J].Oncogene,2004,23:546-53.
  • 3Lee SA,Roques C,Magwood A C,et al.Recovery of deficient homologous recombination in Brca2-depleted mouse cells by wild-type Rad51 expression[J].DNA Repair(Amst),2009,8(2):170-81.
  • 4Klein H L.The consequences of Rad51 overexpression for normal and tumor cells[J].DNA Repair(Amst),2008,7,686-93.
  • 5Lazaro-Trueba I,Arias C,Silva A.Double bolt regulation of Rad51 by p53:a role for transcriptional repression[J].Cell Cycle,2006,5:1062-5.
  • 6Martin R W,Orelli B J,Yamazoe M,et al.RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors[J].Cancer Res,2007,67:9658-65.
  • 7Martin R W,Connell P P,Bishop D K.The Yin and Yang of treating BRCA-deficient tumors[J].Cell,2008,132:919-20.
  • 8Hasselbach L,Haase S,Fischer D,et al.Characterisation of the promoter region of the human DNA-repair gene Rad51[J].Eur J Gynaecol Oncol,2005,26:589-98.
  • 9Wang Z,Dong H,Fu Y,et al.RAD51 135G》C polymorphism contributes to breast cancer susceptibility:a meta-analysis involving 26,444 subjects[J].Breast Cancer Res Treat,2010,124(3):765-9.
  • 10Romanowicz-Makowska H,Smolarz B,Zadrozny M,et al.Analysis of RAD51 polymorphism and BRCA1 mutations in Polish women with breast cancer[J].Exp Oncol,2006,28(2):156-9.

二级参考文献29

  • 1Richardson C. RAD5 1 , genomic stability, and tumorigenesis [J]. Cancer Lett, 2005, 218(1) :127-139.
  • 2Klein H L. The consequences of Rad51 over-expression for nomal and tumor cells [ J ] . DNA Repair ( Amst ) , 2008 , 7 (5) :686-693.
  • 3Bahassi E M, Ovesen J L, Riesenberg A L, et al. The checkpoint kinase chk 1 and chk 2 regulate the functional associations between hBRCA2 and Rad 51 in response to DNA damage [J]. Oncogene, 2008,27(28) :3977-3985.
  • 4Adimoolam S, Sirisawad W, Chen J, et al. ItDAC inhibitor PC 1-24781 decrease RAD51 expression and inhibits homologous recombination [ J ]. Proc Natl Acad Sci USA, 2007, 104(49) :19484-19487.
  • 5Maacke H, Jost H, Opitz S, et al. DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma [ J ]. Oncogene, 2000, 19 ( 21 ) : 2791 -2795.
  • 6Webb P M, Hopper J L, Newman B, et al. Double-strand break repair gene polymorphims and risk of breast or ovarian cancer [ J ] . Cancer Epidemiol Biomarker Prev, 2005 , 14(2) :319-323.
  • 7Kretzner L, Blackwood E M, Eisenman R N. Myc and max proteins possess distinct trancriptional activities [ J ]. Nature, 1992,359(6394) :426-429.
  • 8Mac Partlin M, Homer E, Robinson H, et al. Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with C-Myc and MAX[J]. Oncogene, 2003, 22(6) : 819- 825.
  • 9Hurlin P J, Huang J. The MAX-interacting transciption factor network [J]. Semin Cancer Biol,2006, 16 (14) : 265 -274.
  • 10Hurlin P J, Degouli S. Funtions of Myc : max in the control of cell proliferation and tumorigenesis [ J ]. Int Rev Cytol, 2004,238(2) :183-226.

共引文献4

同被引文献63

引证文献9

二级引证文献26

临床与实验病理学杂志
2011年 第1期

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