树枝状聚合物在靶向给药中的应用进展

Application of dendrimer in targeted drug delivery: recent progress

树枝状聚合物是一种人工合成的新型纳米材料,具有天然的纳米尺寸、独特的单分散性、表面多官能团等特点。这些独特的理化性质使其在生物医学领域得到了广泛地应用,尤其在靶向药物传递方面。药物可包封在树枝状聚合物的内部空腔,也可通过化学键偶联在其表面的官能基团上。表面众多的官能团还可与各种靶向配基如抗体和其Fab片段、叶酸、生物素等偶联,从而将药物传递至配基靶向部位,实现靶向治疗。本文主要探讨树枝状聚合物在靶向药物传递中的应用,并简单介绍这种聚合物的毒性作用。

Dendrimer is a newly synthesized nano-material with natural nanometer-size,unique monodispersion,and multifunctional surface groups.And all these unique properties have led to its wide use in biomedical domain,especially in targeted drug delivery.The drug molecules can be either encapsulated in the hydrophobic chambers inside the dendritic skeleton,or chemically conjugated to the functional groups on the surface of dendrimer.The multifunctional surface groups can be linked chemically to various target ligands,including monoantibody and its Fab fragment,folic acid,biotin,etc,which lead to the delivery of drugs to the targeted sites for targeted therapy.This article mainly discusses the application of dendrimers in targeted drug delivery and introduces the toxic property of dendrimer.