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直肠癌组织中CD70蛋白的表达及意义 被引量：2

Expression and significance of CD70 in rectal cancer tissue
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摘要 目的探讨直肠癌组织中CD70(TNFSF7)蛋白的表达及其临床意义。方法采用免疫组化SP法检测60例直肠癌组织及癌旁组织中CD70、CD27(TNFRSF7)蛋白的表达,分析其与临床病理学特征的关系。结果 CD27、CD70在直肠癌组织中的阳性表达率分别为1.67%、33.33%;在直肠癌旁组织中均不表达。结论 CD70与直肠癌的发生发展密切相关,可作为判断肿瘤分期、指导治疗和预后判断的参考指标。 Objective To explore the expression and significance of CD70 in rectal cancer tissue of CD70（TNFSF7） in patients with rectal cancer.Methods The expressions of CD70 and CD27（TNFRSF7） were detected with immunohistochemical stain method in 60 rectal cancer tissues and tumor-adjacent normal tissues.The relationship between the expressions of CD70 and CD27 and clinicopathological features were analyzed.Results The positive expression rates of CD27 and CD 70 were 1.67% and 33.33%,respectively,which were all zero in the tumor-adacent tissues.ConclusionThe expression of CD70 is closely related to the oncogenesis and development of rectal cancer and could be taken as an useful maeker for evaluating the stage,treatment and prognosis.
作者 谢锡驹 王锋 李小腾 孙琳
机构地区 南京医科大学第一附属医院普通外科
出处 《江苏医药》 CAS CSCD 北大核心 2011年第1期54-56,共3页 Jiangsu Medical Journal
关键词 CD70(TNFSF7) CD27(TNFRSF7) 直肠癌 CD70（TNFSF7） CD27（TNFRSF7） Rectal carcinoma
分类号 R735 [医药卫生—肿瘤]
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参考文献11

  • 1Keller AM, Schildkneeht A, Xiao Y, et al. Expression of costimulatory ligand CD70 on steady-state dendritic cells breaks CD8+ T cell tolerance and permits effective immunity[J]. Immunity, 2008,29 (6) : 934-946.
  • 2Schildknecht A, Miescher I, Yagita H, et al. Priming of CD8+ T cell responses by pathogens typically depends on CD70- mediated interactions with dendritic cells[J]. Eur J Immunol, 2007,37(3) :716-728.
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  • 5Keller AM, Xiao Y, Peperzak V, et al. Costimulatory ligand CD70 allows induction of CD8+ T-cell immunity by immature dendritic cells in a vaccination setting[J]. Blood, 2009, 113 (21) 5167-5175.
  • 6Diegmann J,Junker K,Gerstmayer B, et al. Identification of CD70 as a diagnostic biomarker for clear cell renal cell carcinoma by gene expression profiling, real-time RT-PCR and immunohistochemistry[J] . Eur J Cancer, 2005,41 (12) : 372- 376.
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同被引文献32

  • 1Keller AM, Xiao Y, Peperzak V, et al. Costimulatory ligand CD70 allows induction of CD8+ T cell immunity by immature dendritic cells in a vaccination setting [J]. Blood,2009,113(21):5167-5175.
  • 2Di Mitri D, Azevedo RI, Henson SM, et al. Reversible senescence in human CD4+CD45RA+CD27- memory T cells [J]. Immunol,2011, 187(5):2093-2100.
  • 3Satpathy S, Shenoy GN, Kaw S, et al. Inhibition of terminal differentiat ion of B cells mediated by CD27 and CD40 involves signaling through JNK [J]. Immunol,2010,185(11):6499-6507.
  • 4Hayakawa Y, Sato-Matsushita M, Takeda K, et al. Early activation and interferon-γ production of tumor-infiltrating mature CD27 (high) natural killer cells [J]. Cancer Sci,2011,102(11):1967-1971.
  • 5Fu B, Wang F, Sun R, et al. CDllb and CD27 reflect distinct population and functional specialization in human natural killer cells [J]. Immunology,2011,133(3):350-359.
  • 6Keller AM, Schildknecht A, Xiao Y, et al. Expression of costimulatory ligand CD70 on steady-state dendritic cells breaks CD8+ T cell tolerance and permits effective immunity [J]. Immunity,2008,29(6): 9 34-946.
  • 7Diegmann J, Junker K, Gerstmayer B, et al. Identification of CD70 as a diaglaostic biomarker for clear cell renal cell carcinoma by gene expression profiling, real-time RT-PCR and immunohistochemistry [J]. Eur J Cancer,2005,41(12):372-376.
  • 8Held-Feindt J, Mentlein R. CD70/CD27 ligand, a member of the TNF tamily, is expressed in human brain tumors [J]. Int J Cancer,2002,98( 3):352-356.
  • 9McZEarcherm JA, Oflazoglu E, Francisco L, et al. Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitum or activities [J]. Blood,2007,109(3): 1185 - 1192.
  • 10Pepe CA, Ricci R, Cortelazzi C, et al. The vast majority of lymphocytes infiltrating primary cutaneous melanoma express the CD27 costimulatory receptor: implications for melanoma progression [J]. Eur J Dermatol,2011,21 (2): 178-183.

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江苏医药
2011年 第1期

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