CTGF和VEGF在胃癌组织中的表达及意义

Expression and significance of CTGF and VEGF in gastric carcinoma

目的探讨结缔组织生长因子(CTGF)与血管内皮生长因子(VEGF)在胃癌组织中的表达及其意义。方法应用免疫组织化学方法检测64例胃癌组织和癌旁正常组织中CTGF、VEGF的表达,分析其与胃癌临床病理因素之间的关系和意义。结果胃癌组织中CTGF、VEGF的阳性表达率均明显高于正常组织(P<0.05);CTGF的高表达与胃癌的分化程度、淋巴结转移与否、临床分期密切相关(P<0.05);VEGF的高表达与胃癌的临床分期和淋巴结转移密切相关(P<0.05)。胃癌组织中CTGF和VEGF的表达呈正相关关系(P<0.05)。结论 CTGF和VEGF在胃癌组织中均呈现高表达,并且与胃癌的临床分期、淋巴结转移与否有关;联合检测CTGF和VEGF可作为胃癌早期诊断和预后判断的指标。

Objective To investigate the expression and significance of connective tissue growth factor（CTGF） and vascular endothelial growth factor（VEGF） in gastric carcinoma.Methods The expressions of CTGF and VEGF in cancer and tumor-adjacent normal tissues in 64 patients with grastic cancer were examined by immunohistochemistry.Results The expressions of CTGF and VEGF were higher in gastric carcinoma than those in normal tissues（P0.05）.Overexpression of CTGF was correlated with the degree of differentiation,lymph node metastasis and clinical stage（P0.05）.Overexpression of VEGF was correlated with the clinical stage and lymph node metastasis（P0.05）.CTGF expression was positively correlated to VEGF in gastric carcinoma（P0.05）.Conclusion CTGF and VEGF are overexpressed in gastric carcinoma,which is associated with clinical stage and lymph node metastasis of gastric carcinoma.Combined detection of CTGF and VEGF may be taken as the marker in early diagnosis and evaluating the prognosis of gastric carcinoma.