摘要
目的通过分析冠心病患者及冠脉正常组中结合珠蛋白（haptoglobin，HP）基因1／2多态性分布，初步探讨HP基因1／2多态性与冠心病易感性的关系。方法经冠脉造影确诊冠心病组189例，冠脉正常对照组242名；采用聚合酶链反应-限制性片段长度多态性技术检测所有受试者HP基因型。结果冠心病组HP基因型分布与对照组相比差异有统计学意义（P=0．002），表现为HP2-2基因型在冠心病组的频率明显高于对照组（0．54 vs．0．35，P=0．000），单因素分析显著增加冠心病的风险（OR=2．166，95％CI：1．467～3．196），HP2等位基因的频率也明显高于对照组（0．74 vs．0．61）。同时，多因素Logistic回归分析表明HP2-2基因型是冠心病的独立危险因素（P=0．002；OR-2．101，95％CI：1．311～3．367）。结论HP2-2基因型与冠心病的发生相关，可能是冠心病发病的独立危险因子；HP2等位基因可能是中国人冠心病的易感基因。
Objective To assess the association of haptoglobin （HP）1/2 polymorphism with coronary heart disease （CHD） in Chinese Hans. Methods One hundred and eighty-nine CHD patients and 242 healthy controls confirmed with angiography were recruited. Polymerase chain reactiowrestriction fragment length polymorphism （PCR-RFLP） method was utilized to genotype the HP1 and HP2 alleles and genotype frequencies in cases and controls were compared. Results The frequency of HP2-2 genotype was significantly higher in CHDs than in controls （0.54 vs. 0.35, P=0. 000）. The HP2-2 genotype significantly increased the risk for CHD in univariable analysis （OR = 2. 166, 95% CI： 1. 467-3. 196）. Multifactor Logistic regression analysis indicated that HP2-2 genotype is an independent risk factor to CHD （P= 0. 002; OR= 2. 101, 95% CI： 1. 311-3. 367）. Similarly, the HP2 allele frequency in the CHD group was significantly higher than that in the control subjects （0.74 vs. 0. 61, P=0. 000）. Conclusion The HP2-2 genotype is associated with CHD in Chinese. HP2-2 genotype may be an independent risk factor to CHD, and HP2 allele may be a genetic susceptibility factor to CHD in Chinese.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
2011年第1期60-63,共4页
Chinese Journal of Medical Genetics
基金
浙江省自然科学基金（Y206531）
