铜绿假单胞菌医院获得性肺炎的临床调查

Clinical investigation of hospital acquired pneumonia caused by pseudomonas aeruginosa

目的了解铜绿假单胞菌医院获得性肺炎的临床特点。方法分析366例铜绿假单胞菌医院获得性肺炎患者的症状、体征、肺部影像学改变、痰细菌培养、药敏情况及治疗转归等。结果铜绿假单胞菌医院获得性肺炎多发生于有基础疾病的患者,特别是肺部有基础疾病及免疫功能受损患者;铜绿假单胞菌具有多药耐药性,对常用抗菌药物的耐药率在33.41%~96.37%;患者住院病死率为45.08%;医院获得性肺炎的发生存在多种危险因素。结论铜绿假单胞菌医院获得性肺炎多见于有基础疾病患者,存在多药耐药性,病死率高,应加强病原菌的监测及医院感染的控制。

OBJECTIVE To study the clinical characteristics of hospital acquired pneumonia caused by Pseudomonas aeruginosa.METHODS Statistical analysis of symptoms,signs,imaging changes in pulmonary,sputum bacteria culture,drug sensitivity and therapeutic outcomes etc in 366 cases of hospital acquired pneumonia caused by P.aeruginosa was performed.RESULTS Most cases of hospital acquired pneumonia caused by P.aeruginosa occurred in patients with primary diseases,especially with pulmonary basis diseases or immune function depression.In these cases,clinical symptoms and signs were not specific.And these cases were diagnosed by sputum bacteria culture.P.aeruginosa was multi-drug resistant.The drug resistant rate to common antibiotics was 33.41%-96.37%.The hospital mortality was 45.08%.The incidence of hospital acquired pneumonia was relative to multiple risk factors.CONCLUSION Most cases of hospital acquired pneumonia caused by P.aeruginosa,with high mortality,occur in patients with basis diseases.P.aeruginosa is multi-drug resistant.So,The monitoring of pathogen and the control of hospital infection infection should be strengthened.