呼吸道感染患者铜绿假单胞菌耐药性分析

Drug Resistance Analysis of Pseudomonas aeruginosain Patients with Respiratory Trace Infection

目的了解医院呼吸道感染患者铜绿假单胞菌耐药谱变化,为临床预防感染以及合理用药提供依据。方法回顾性调查医院2007年6月-2008年12月下呼吸道感染患者痰标本培养情况,对分离的158株铜绿假单胞菌药敏试验结果进行统计分析。结果从359份标本中分离出铜绿假单胞菌158株,总分离率为44.01%,铜绿假单胞菌对亚胺培南的体外抗菌性最好,耐药率为16.46%,其次为哌拉西林/他唑巴坦21.52%;耐药率最高的是磺胺甲噁唑/甲氧苄啶、氨苄西林、头孢唑林,均为100.00%。结论铜绿假单胞菌的分离率及耐药率较高,且耐药性严重,对多药耐药菌株的感染应以预防为主,建立耐药监控体系,加强耐药性监测,合理选用抗菌药物,以减少耐药菌株的出现。

OBJECTIVE To study resistance and the change of Pseudomonas aeruginosa of respiratory system infection,and offers basis for prevention of clinical infection and the reasonable use of drugs.METHODS The respiratory system infection patients from Jun 2007 to Dec 2008 were investigated.To the results of MICs with158 P.aeruginosa strains were analyzed.RESULTS A total of 158 strains of P.aeruginosa were isolated from 359 specimens,which accounted for 44.01%.Imipenem had the best antibiotic activity and with the lowest drug resistance rate（16.46%）,followed by Piperacillin/Tazobactam（21.52%）,Trimethop rim/Sulfa 100.00%,Ampicillin 100.00%,Cefazolin 100.00%.CONCLUSIONS The resistance of the isolates is serious.For the reason that we should strengthen monitoring of resistance,choose reasonably to apply antibiotics in order to reduce drug-resistant strains.and to establish a drug resistance monitoring system to prevent hospital infection,detect the pathogenic bacteria and use antibiotics rationally.